• <xmp id="gswu8"><nav id="gswu8"></nav>
  • <nav id="gswu8"><strong id="gswu8"></strong></nav><nav id="gswu8"></nav>
    phthalic anhydride
    CAS No.: 85-44-9 Formula: C8H4O3 Molecular Weight: 148.11600
    Search Suppliers

    phthalic anhydride

    CAS No.: 85-44-9 Formula: C8H4O3 Molecular Weight: 148.11600
    Suppliers: All (83) China Suppliers (83) Price Available (15) Contractor (11)


    Phthalic anhydride is the organic compound with the formula C6H4(CO)2O. It is the anhydride of phthalic acid. Phthalic anhydride is a principal commercial form of phthalic acid. It was the first anhydride of a dicarboxylic acid to be used commercially. This colourless solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. In 2000, the worldwide production volume was estimated to be about 3 million tonnes per year.

    Numbering system

    EINECS number 201-607-5
    MDL number MFCD00005918


    Appearance & Physical State white crystalline solid with choking odour
    Density 1.53
    Boiling Point 284oC
    Melting Point 129-132oC
    Flash Point 152oC
    Refractive Index 1.646
    Water Solubility 6 g/L (20 oC)
    Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, moisture, strong acids. Dust may form an explosive mixture with air.
    Storage Condition Store at RT.
    Vapor Density 5.1 (vs air)
    Vapor Pressure <0.01 mm Hg ( 20 °C)

    Safety Info

    RTECS TI3150000
    Hazard Class 8
    Safety Statements S22-S24/25-S26-S37/39-S46
    HS Code 2917350000
    WGK Germany 1
    Packing Group III
    RIDADR UN 2214
    Risk Statements R22; R37/38; R41; R42/43
    Hazard Codes Xn
    SDS 1.0 Expand

    SDS 1.0

    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search


    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017


    1.1 GHS Product identifier

    Product name phthalic anhydride

    1.2 Other means of identification

    Product number -
    Other names 1,3-DIHYDRO-IMIDAZOL-2-ONE

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Phthalic anhydride is an important chemical intermediate in the plastics industry from which are derived numerous phthalate esters that function as plasticizers in synthetic resins. Phthalic anhydride itself is used as a monomer for synthetic resins such as glyptal, the alkyd resins, and the polyester resins. Phthalic anhydride is also used as a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and xanthene dyes. Phthalic anhydride is used in the synthesis of primary amines, the agricultural fungicide phaltan, and thalidomide. Other reactions with phthalic anhydride yield phenolphthalein, benzoic acid, phthalylsulfathiazole (an intestinal antimicrobial agent), and orthophthalic acid.
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    Skin irritation, Category 2

    Serious eye damage, Category 1

    Skin sensitization, Category 1

    Specific target organ toxicity – single exposure, Category 3

    Respiratory sensitization, Category 1

    2.2 GHS label elements, including precautionary statements

    Signal word


    Hazard statement(s)

    H302 Harmful if swallowed

    H315 Causes skin irritation

    H318 Causes serious eye damage

    H317 May cause an allergic skin reaction

    H335 May cause respiratory irritation

    H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

    Precautionary statement(s)

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P271 Use only outdoors or in a well-ventilated area.

    P284 [In case of inadequate ventilation] wear respiratory protection.


    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P313 If skin irritation occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P310 Immediately call a POISON CENTER/doctor/…

    P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...


    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    P405 Store locked up.


    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification


    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    phthalic anhydride phthalic anhydride 85-44-9 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Half-upright position. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Solid irritates skin and eyes, causing coughing and sneezing. Liquid causes severe thermal burns. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    First aid: Inhalation - Fresh air, rest. Half-upright position. Refer for medical attention. Skin - Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. Eyes - First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. Ingestion - Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

    5.2 Specific hazards arising from the chemical

    Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Dry. Well closed.Chemical stability: Stable under recommended storage conditions.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 6 mg/cu m (1 ppm).

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state white crystalline solid with choking odour
    Colour White, lustrous needles
    Odour Mild
    Melting point/ freezing point 275°C(lit.)
    Boiling point or initial boiling point and boiling range 284°C(lit.)
    Flammability Combustible SolidCombustible.
    Lower and upper explosion limit / flammability limit Lower flammable limit: 1.7% by volume; Upper flammable limit: 10.5% by volume
    Flash point 64°C(lit.)
    Auto-ignition temperature 570°C (USCG, 1999)
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 1.19 mPa.s at 132°C; 1.125 mPa.s at 155°C
    Solubility In water:6 g/L (20 oC)
    Partition coefficient n-octanol/water (log value) log Kow = 1.60
    Vapour pressure <0.01 mm Hg ( 20 °C)
    Density and/or relative density 1.53
    Relative vapour density 5.1 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    Combustible solidDust explosion possible if in powder or granular form, mixed with air.PHTHALIC ANHYDRIDE reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Undergoes exothmeric nitration with fuming nitric acid-sulfuric acid and may give mixtures of the potentially explosive phthaloyl nitrates or nitrites or their nitro derivatives [Chem. & Ind. 20:790. 1972]. Phthalic anhydride reacts violently with CuO at elevated temperatures [Park, Chang-Man, Richard J. Sheehan. "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 2005]. Mixtures of phthalic anhydride and anhydrous CO2 explode violently if heated [Leaflet No. 5, Inst. of Chem., London, 1940].

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Strong oxidizers, water [Note: Converted to phthalic acid in hot water].

    10.6 Hazardous decomposition products

    Phthalic anhydride hydrolyzes rapidly in the presence of water forming phthalic acid. Half-life for phthalic anhydride was 30.5 seconds at pH 7.24. At pH 6.8 the half-life of phthtalic anhydride in water was prolonged to 61 seconds.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 800-1600 mg/kg
    • Inhalation: LC50 Rat inhalation >210 mg/L/1 hr
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    A4; Not classifiable as a human carcinogen.

    Reproductive toxicity

    No studies regarding reproductive or developmental effects in humans were available. Phthalic anhydride was reported to be teratogenic in mice following intraperitoneal injection. Decreased spermatozoa motility time was reported in one study in which male rats were exposed via inhalation.

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: EC50; Species: Danio rerio (Zebra danio); Conditions: freshwater; renewal; Concentration: 561000 ug/L (95% confidence limit: 320000 to 1000000 ug/L) for 7 days; Effect: developmental, teratogenic measurements /formulated product
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae); Conditions: freshwater; static; Concentration: 41400 ug/L (95% confidence limit: 0 to 109100 ug/L) for 96 hr; Effect: population, biomass /active ingredient
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: Based on the available experimental biodegradation test results, phthalic anhydride can be classified as readily biodegradable(1). However, phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25°C(1,2), and biodegradation test results may be reflective of biodegradation of phthalic acid which is the hydrolysis product of phthalic anhydride(1,2). Phthalic anhydride, present at 100 mg/L, reached 85.2% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3); it was noted that the phthalic anhydride had been hydrolyzed to phthalic acid(3). Using OECD Method 301D (closed bottle test) and a domestic sewage inoculum, phthalic anhydride reached 71% of theoretical BOD after 30 days(1). Phthalic anhydride was reported to have a 5 day theoretical oxygen demand of 73.46% using 0.5 ppm concentration with a sewage inoculum(4). Theoretical BOD was reported to be 44-78% as a result of incubation of 1-4 ppm with sewage inoculum(5). Reported degradation of an initial concentration of 2 ppm phthalic anhydride was approximately 22% after incubation with sewage (standard dilution method) and 18% (seawater dilution method) for 5 days(6). Mineralization of 33% of an initial concentration of 9 ppm phthalic anhyride incubated with activated sludge for 24 hrs was reported based on chemical oxygen demand(7). Phthalic anhydride degradation using an acclimated activated sludge gave a 33% chemical oxygen demand and 88% total organic carbon in 24 hours(8).

    12.3 Bioaccumulative potential

    An estimated BCF of 5 was calculated in fish for phthalic anhydride(SRC), using a log Kow of 1.60(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Phthalic anhydride did not bioconcentrate in Gambusia (mosquito fish)(4). Phthalic anhydride has a reported BCF of 4,053 in Oedogonium (alga) but did not bioconcentrate in Daphnia (water flea) or Physa (snail)(4). Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25°C(1,5) which suggests that bioconcentration in fish may not be an important fate process(SRC).

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc of phthalic anhydride can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that phthalic anhydride is expected to have very high mobility in soil. Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25°C(3,4) which suggests that leaching may not be an important fate process(SRC).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN2214 IMDG: UN2214 IATA: UN2214

    14.2 UN Proper Shipping Name

    ADR/RID: PHTHALIC ANHYDRIDE with more than 0.05% of maleic anhydride
    IMDG: PHTHALIC ANHYDRIDE with more than 0.05% of maleic anhydride
    IATA: PHTHALIC ANHYDRIDE with more than 0.05% of maleic anhydride

    14.3 Transport hazard class(es)

    ADR/RID: 8 IMDG: 8 IATA: 8

    14.4 Packing group, if applicable


    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    phthalic anhydride phthalic anhydride 85-44-9 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%


    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3


    C8 H4 O3 0.040 g : 0.5 ml CDCl3
    phthalic anhydride

    Assign. Shift(ppm)
    A 8.03
    B 7.95

    IR : KBr discExpand
    Mass Expand
    Recommended Suppliers
    More Suppliers>>
    Other items you might be interested in
    Category in MOLBASE