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    dimethyl sulfate
    CAS No.: 77-78-1 Formula: C2H6O4S Molecular Weight: 126.13200
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    dimethyl sulfate

    CAS No.: 77-78-1 Formula: C2H6O4S Molecular Weight: 126.13200
    Suppliers: All (39) China Suppliers (39) Price Available (5) Contractor (7)

    Description

    Dimethyl sulfate is a chemical compound with formula (CH3O)2SO2. As the diester of methanol and sulfuric acid, its formula is often written as (CH3)2SO4 or even Me2SO4, where CH3 or Me is methyl. Me2SO4 is mainly used as a methylating agent in organic synthesis.
    Under standard conditions, Me2SO4 is a colourless oily liquid with a slight onion-like odour (although smelling it would represent significant exposure). Like all strong alkylating agents, Me2SO4 is extremely toxic. Its use as a laboratory reagent has been superseded to some extent by methyl triflate, CF3SO3CH3, the methyl ester of trifluoromethanesulfonic acid.

    Numbering system

    UNII JW5CW40Z50

    Properties

    Appearance & Physical State Clear oily liquid
    Density 1.333
    Boiling Point 188oC
    Melting Point -32oC
    Flash Point 83oC
    Refractive Index 1.386-1.388
    Stability Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
    Storage Condition 2-8oC

    Safety Info

    Hazard Class 6.1(a)
    Safety Statements S45-S53
    HS Code 2920909090
    RIDADR UN 1595
    Risk Statements R25; R26; R34; R43; R45; R68
    Hazard Codes T+
    Hazard Declaration H301; H314; H317; H330; H341; H350
    Signal Word Danger
    Caution Statement P201; P260; P280; P301 + P310 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338; P308 + P313; P403 + P233
    Symbol GHS05, GHS06, GHS08
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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name dimethyl sulfate

    1.2 Other means of identification

    Product number -
    Other names Sulfuric acid, dimethyl ester

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Dimethyl sulfate is used as a methylating agent in the manufacture of many organic chemicals. It is also used in the manufacture of dyes and perfumes, for the separation of mineral oils, and for the analysis of auto fluids. (-) Formerly, dimethyl sulfate was used as a war gas. (-4)
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 3

    Skin corrosion, Category 1B

    Skin sensitization, Category 1

    Acute toxicity - Inhalation, Category 2

    Germ cell mutagenicity, Category 2

    Carcinogenicity, Category 1B

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H314 Causes severe skin burns and eye damage

    H317 May cause an allergic skin reaction

    H330 Fatal if inhaled

    H341 Suspected of causing genetic defects

    H350 May cause cancer

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P271 Use only outdoors or in a well-ventilated area.

    P284 [In case of inadequate ventilation] wear respiratory protection.

    P201 Obtain special instructions before use.

    P202 Do not handle until all safety precautions have been read and understood.

    Response

    P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P310 Immediately call a POISON CENTER/doctor/…

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P320 Specific treatment is urgent (see ... on this label).

    P308+P313 IF exposed or concerned: Get medical advice/ attention.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    dimethyl sulfate dimethyl sulfate 77-78-1 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.

    In case of eye contact

    Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

    If swallowed

    Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.

    4.2 Most important symptoms/effects, acute and delayed

    Acute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities. (EPA, 1998)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    IN ALL CASES CONSULT A DOCTOR! INHALATION: Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. SKIN: Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. EYES: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: Rinse mouth. Give plenty of water to drink. Refer for medical attention immediately.

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Water, foam, carbon dioxide, dry chemical ... .

    5.2 Specific hazards arising from the chemical

    Material is normally stable even under fire exposure conditions and is not hazardously reactive with water. It is incompatible with strong oxidizers and strong ammonia solutions. (EPA, 1998)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    Spillage should only be dealt with by trained personnel wearing full protective clothing, a full-face mask, and positive-pressure breathing apparatus. Soda ash or 3% ammonia solution may be applied to liquid spills. Sprays of 3% ammonia solution may be used to "knock down" the vapor over spillages. After complete neutralization, spillages may be washed away... If dimethyl sulfate has entered a watercourse ... or contaminated soil or vegetation, advise the police and public authorities.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator, or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... . Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    NIOSH considers dimethyl sulfate to be a potential occupational carcinogen.

    Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.1 ppm (0.5 mg/cu m), skin.

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Clear oily liquid
    Colour Colorless oily liquid
    Odour Essentially odorless
    Melting point/ freezing point 63°C(lit.)
    Boiling point or initial boiling point and boiling range 188°C(lit.)
    Flammability Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit no data available
    Flash point 83°C
    Auto-ignition temperature 495°C
    Decomposition temperature 188°C
    pH no data available
    Kinematic viscosity no data available
    Solubility 3 % at 17.78°C (NIOSH, 2016)
    Partition coefficient n-octanol/water (log value) log Kow = 0.16 (est)
    Vapour pressure 0.1 to 0.5 mm Hg at 20°C (EPA, 1998)
    Density and/or relative density 1.333g/mLat 25°C(lit.)
    Relative vapour density 4.3 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable at room temperature.

    10.3 Possibility of hazardous reactions

    MODERATE, WHEN EXPOSED TO HEAT OR FLAME.Pure DIMETHYL SULFATE and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110° C was allowed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as dimethyl sulfate, [MCA Case History No. 1786].

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Can react with oxidizing materials.

    10.6 Hazardous decomposition products

    Note: Decomposes in water to sulfuric acid; corrosive to metals.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Mouse oral 140 mg/kg bw
    • Inhalation: LC50 Guinea pig inhalation 167 mg/cu m (32 ppm)/60 min.
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    Evaluation: There is inadequate evidence for the carcinogenicity in humans of dimethyl sulfate. There is sufficient evidence for the carcinogenicity in experimental animals of dimethyl sulfate. Overall evaluation: Dimethyl sulfate is probably carcinogenic to humans (Group 2A). In making the overall evaluation, the Working Group took into consideration that dimethyl sulfate is a potent genotoxic chemical which can directly alkylate DNA both in vitro and in vivo.

    Reproductive toxicity

    No information is available on the reproductive or developmental effects of dimethyl sulfate in humans. Dimethyl sulfate has been reported to produce tumors in the offspring of rats exposed intravenously.

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill, length 33-75 mm); Conditions: freshwater, static, 23°C, pH 7.6-7.9, hardness 55 mg/L CaCO3; Concentration: 7500 ug/L for 96 hr /99% purity
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    no data available

    12.3 Bioaccumulative potential

    Based upon the hydrolysis of dimethyl sulfate in aqueous environments(1), bioconcentration is not expected to be a primary removal process in aquatic systems(SRC).

    12.4 Mobility in soil

    Based upon the hydrolysis of dimethyl sulfate in aqueous environments(1), adsorption to soil and leaching are not expected to be important processes(SRC).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1595 IMDG: UN1595 IATA: UN1595

    14.2 UN Proper Shipping Name

    ADR/RID: DIMETHYL SULPHATE
    IMDG: DIMETHYL SULPHATE
    IATA: DIMETHYL SULPHATE

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    dimethyl sulfate dimethyl sulfate 77-78-1 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : parameter in CDCl3Expand

    NMR Spectrum 1H NMR : parameter in CDCl3

    Collapse

    C2 H6 O4 S 0.04 ml : 0.5 ml CDCl3
    dimethyl sulfate

    Parameter ppm Hz
    D(A) 3.960

    IR : liquid filmExpand
    Mass Expand
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