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    1-Bromobutane
    CAS No.: 109-65-9 Formula: C4H9Br Molecular Weight: 137.01800
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    1-Bromobutane

    CAS No.: 109-65-9 Formula: C4H9Br Molecular Weight: 137.01800
    Suppliers: All (89) China Suppliers (89) Price Available (14) Contractor (18)

    Description

    1-Bromobutane is used in the synthesis of procaine and tetracaine.

    Basic Info

    Chemical Name 1-Bromobutane
    Synonyms

    1-Butyl-biuret; 1-bromo-n-butane; 1-Bromobutan; n-butylbromide; 1-bromo-butane; bromobutane; n-Butylbiuret; Butyl Bromide; N-Bromobutane; 1-butyl bromide; Butane, 1-bromo-; n-Butyl bromide; Expand

    CAS No. 109-65-9
    Molecular Formula C4H9Br
    Molecular Weight 137.01800
    PSA 0.00000
    LogP 2.18140

    Numbering system

    MDL number MFCD00000260
    RTECS number EJ6225000
    EINECS number 203-691-9
    BRN number 1098260
    PubChem number 1098260

    Properties

    Appearance & Physical State clear colorless to slightly yellow liquid
    Density 1.276
    Boiling Point 100-104oC
    Melting Point -112oC
    Flash Point 23oC
    Refractive Index 1.4384-1.4404
    Water Solubility 0.608 g/L (30 oC)
    Stability Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases.
    Storage Condition Flammables area
    Vapor Density 4.7 (vs air)
    Vapor Pressure 150 mm Hg ( 50 °C)

    Safety Info

    RTECS EJ6225000
    Hazard Class 3
    Safety Statements S16-S26-S37/39
    HS Code 2903399090
    Packing Group II
    WGK Germany 2
    RIDADR UN 1126
    Risk Statements R10; R36/37/38
    Hazard Codes Xi
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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 10, 2017

    Revision Date: Aug 10, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name 1-Bromobutane

    1.2 Other means of identification

    Product number -
    Other names n-Butylbiuret

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates,Solvents (for cleaning or degreasing)
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 2

    Skin irritation, Category 2

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H315 Causes skin irritation

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P313 If skin irritation occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    1-Bromobutane 1-Bromobutane 109-65-9 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

    In case of skin contact

    Wash off with soap and plenty of water. Consult a physician.

    In case of eye contact

    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

    If swallowed

    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

    4.2 Most important symptoms/effects, acute and delayed

    Irritating to the eyes, nose, throat, and upper respiratory tract. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Irritating to the skin. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Absorption, Distribution and Excretion

    /n-Butyl bromide administered orally (at the LD50) was deposited mainly in the brain, liver, and perirenal cellular system, and excreted primarily by the lungs./

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    To fight fire use carbon dioxide, dry chemical, mist or spray.

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Toxic fumes of hydrogen bromide. Behavior in Fire: May form explosive mixtures with air in fire. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

    6.3 Methods and materials for containment and cleaning up

    Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Materials which are toxic as stored or which can decomp into toxic components... should be stored in a cool well ventilated place, out of the direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected. Incompatible materials should be isolated...

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state clear colorless to slightly yellow liquid
    Colour Colorless to pale straw-colored liquid
    Odour no data available
    Melting point/ freezing point -112°C(lit.)
    Boiling point or initial boiling point and boiling range 101°C
    Flammability no data available
    Lower and upper explosion limit / flammability limit Lower (2.6%), Upper (6.6%)
    Flash point 13°C
    Auto-ignition temperature 265°C (USCG, 1999)
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 0.606 mPa-sec at 25°C
    Solubility In water:0.608 g/L (30 oC)
    Partition coefficient n-octanol/water (log value) log Kow = 2.75
    Vapour pressure 150 mm Hg ( 50 °C)
    Density and/or relative density 1.276
    Relative vapour density 4.7 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    Dangerous fire hazard when exposed to heat, flame or oxidizers.1-BROMOBUTANE is incompatible with strong bases and oxidizers (USCG, 1999).

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    It can react with oxidizing materials.

    10.6 Hazardous decomposition products

    no data available

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat (Sprague Dawley, male) oral 2761 mg/kg
    • Inhalation: LC50 Mouse inhalation 237 g/cu m/30 min
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 Pimephales promelas (Fathead minnow) 36.7 mg/L/4 day /Conditions of bioassay not specified in source examined
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: The bacteria Arthrobacter sp. HA-1 was found to have a growth yield of 4.1 g protein/(mol C) on 1-bromobutane(1). Substrate utilization was measured by halide release and in this case a 96% bromine release was measured(1). Arthrobacter sp. HA-1 has been shown to grow on 1-bromobutane at a rate of 0.11 per hour(2).

    12.3 Bioaccumulative potential

    An estimated BCF of 26 was calculated for 1-bromobutane(SRC), using a log Kow of 2.75(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-bromobutane can be estimated to be 80(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-bromobutane is expected to have high mobility in soil.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1126 IMDG: UN1126 IATA: UN1126

    14.2 UN Proper Shipping Name

    ADR/RID: 1-BROMOBUTANE
    IMDG: 1-BROMOBUTANE
    IATA: 1-BROMOBUTANE

    14.3 Transport hazard class(es)

    ADR/RID: 3 IMDG: 3 IATA: 3

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    1-Bromobutane 1-Bromobutane 109-65-9 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 10, 2017
    Revision Date Aug 10, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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