• <xmp id="gswu8"><nav id="gswu8"></nav>
  • <nav id="gswu8"><strong id="gswu8"></strong></nav><nav id="gswu8"></nav>
    Methyl chloroacetate
    CAS No.: 96-34-4 Formula: C3H5ClO2 Molecular Weight: 108.52400
    Search Suppliers

    Methyl chloroacetate

    CAS No.: 96-34-4 Formula: C3H5ClO2 Molecular Weight: 108.52400
    Suppliers: All (66) China Suppliers (66) Price Available (7) Contractor (9)

    Description

    Methyl chloroacetate is widely used in the chemical and biochemical fields as an extraction solvent. Methyl chloroacetate is known to induce DNA damage to rat sperm, and is also thought to be toxic to humans upon exposure. Methyl chloroacetate is also used as a reagent to synthesize Valdecoxib, a selective cyclooxygenase 2(COX-2) specific inhibitor that is used to treat postoperative pain.

    Basic Info

    Chemical Name Methyl chloroacetate
    Synonyms

    methyl 2-chloroacetate; Acetic acid, chloro-, methyl ester;

    CAS No. 96-34-4
    Molecular Formula C3H5ClO2
    Molecular Weight 108.52400
    PSA 26.30000
    LogP 0.39820

    Numbering system

    MDL number MFCD00000931
    EINECS number 202-501-1

    Properties

    Appearance & Physical State Clear liquid
    Density 1.238
    Boiling Point 130-132oC
    Melting Point -33oC
    Flash Point 47oC
    Refractive Index 1.421-1.423
    Water Solubility 28 g/L (20 oC)
    Storage Condition Flammables area
    Vapor Density 3.8 (vs air)
    Vapor Pressure 10 mm Hg ( 25 °C)

    Safety Info

    RTECS AF9500000
    Hazard Class 6.1
    Safety Statements S26-S37/39-S45
    HS Code 2915400090
    WGK Germany 2
    Packing Group I
    RIDADR UN 2295
    Risk Statements R10; R23/25; R37/38; R41
    Hazard Codes T
    SDS 1.0 Expand

    SDS 1.0

    Collapse
    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name Methyl chloroacetate

    1.2 Other means of identification

    Product number -
    Other names Acetic acid, chloro-, methyl ester

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 3

    Acute toxicity - Oral, Category 3

    Skin irritation, Category 2

    Serious eye damage, Category 1

    Acute toxicity - Inhalation, Category 3

    Specific target organ toxicity – single exposure, Category 3

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H226 Flammable liquid and vapour

    H301 Toxic if swallowed

    H315 Causes skin irritation

    H318 Causes serious eye damage

    H331 Toxic if inhaled

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P332+P313 If skin irritation occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P310 Immediately call a POISON CENTER/doctor/…

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P311 Call a POISON CENTER/doctor/…

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Methyl chloroacetate Methyl chloroacetate 96-34-4 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: Note: Most foams will react with the material and release corrosive/toxic gases. CAUTION: For Acetyl chloride (UN1717), use CO2 or dry chemical only. SMALL FIRE: CO2, dry chemical, dry sand, alcohol-resistant foam. LARGE FIRE: Water spray, fog or alcohol-resistant foam. FOR CHLOROSILANES, DO NOT USE WATER; use AFFF alcohol-resistant medium-expansion foam. Move containers from fire area if you can do it without risk. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in covered plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Collect leaking liquid in covered plastic containers.

    6.3 Methods and materials for containment and cleaning up

    Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Clear liquid
    Colour Colorless liquid
    Odour Sweet pungent odor
    Melting point/ freezing point -32°C(lit.)
    Boiling point or initial boiling point and boiling range 130°C
    Flammability Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit LOWER FLAMMABLE LIMIT: 7.5% BY VOLUME; UPPER FLAMMABLE LIMIT: 18.5% BY VOLUME
    Flash point 57°C(lit.)
    Auto-ignition temperature 465°C (USCG, 1999)
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 2.95X10-3 Pa.s @ 241.03 K
    Solubility In water:28 g/L (20 oC)
    Partition coefficient n-octanol/water (log value) 0.76 (calculated)
    Vapour pressure 10 mm Hg ( 25 °C)
    Density and/or relative density 1.238
    Relative vapour density 3.8 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    DECOMPOSES WHEN DISSOLVED IN WATER /SRP: GIVING MONOCHLOROACETIC ACID AND METHANOL/

    10.3 Possibility of hazardous reactions

    Flammable when exposed to heat or flame ...The vapour is heavier than air.METHYL CHLOROACETATE is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    ... Can react vigorously with oxidizing materials.

    10.6 Hazardous decomposition products

    When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Mouse oral 240 mg/kg
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: no data available
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    Methyl chloroacetate, present at 30 mg/l, reached 32-75% of its theoretical BOD in 4 weeks using an activated sludge inoculum at www mg/l and the Japanese MITI test(1); it was hydrolyzed to methanol and monochloroacetic acid(1).

    12.3 Bioaccumulative potential

    An estimated BCF of 3 was calculated for methyl chloroacetate(SRC), using an estimated log Kow of 0.63(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc for methyl chloroacetate can be estimated to be 6(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl chloroacetate is expected to have very high mobility in soil.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN2295 IMDG: UN2295 IATA: UN2295

    14.2 UN Proper Shipping Name

    ADR/RID: METHYL CHLOROACETATE
    IMDG: METHYL CHLOROACETATE
    IATA: METHYL CHLOROACETATE

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Methyl chloroacetate Methyl chloroacetate 96-34-4 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C3 H5 Cl O2 0.02 ml : 0.5 ml CDCl3
    methyl chloroacetate

    Assign. Shift(ppm)
    A 4.08
    B 3.81

    IR : CCl4 solutionExpand
    Mass spectrum (electron ionization)Expand
    Raman : 4880 A,200 M,liquidExpand
    Recommended Suppliers
    More Suppliers>>
    Other items you might be interested in
    Category in MOLBASE
    天天干夜夜操