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    Acetic anhydride
    CAS No.: 108-24-7 Formula: C4H6O3 Molecular Weight: 102.08900

    Acetic anhydride

    CAS No.: 108-24-7 Formula: C4H6O3 Molecular Weight: 102.08900
    Suppliers: All(0) China Suppliers(0) Price Available(0) Contractor(0)

    Description

    Acetic Anhydride is a very useful synthetic intermediate. It is a reagent used generally in acetylation reactions in organic chemistry, primarily cellulose acetate and film material. It is also used in the production of aspirin, which is prepared by the acetylation of salicylic acid.

    Basic Info

    Chemical Name Acetic anhydride
    Synonyms

    Acetic acid, anhydride; acetyl acetate; Acetic acid anhydride;

    CAS No. 108-24-7
    Molecular Formula C4H6O3
    Molecular Weight 102.08900
    PSA 43.37000
    LogP 0.09600

    Numbering system

    BRN number 385737
    PubChem number 24854587
    EINECS number 203-564-8
    RTECS number AK1925000
    MDL number MFCD00008705

    Properties

    Appearance & Physical State Colorless liquid
    Density 1.087
    Boiling Point 140 °C
    Melting Point -73.1 °C
    Flash Point 130?°F
    Refractive Index n20/D 1.390(lit.)
    Water Solubility REACTS
    Stability Stability Flammable. Incompatible with strong oxidizing agents, water, strong bases, alcohols.
    Storage Condition Store at RT.
    Vapor Density 3.5 (vs air)
    Vapor Pressure 10 mm Hg ( 36 °C)

    Safety Info

    RTECS AK1925000
    Hazard Class 8
    Safety Statements S26; S39; S45; S36/37/39
    HS Code 29152400
    Packing Group II
    WGK Germany 3
    RIDADR UN 2924 3/PG 2
    Risk Statements R11; R20/21/22; R37/38; R41; R34; R20/21;
    Hazard Codes C; Xn; F; Xi
    Hazard Declaration H226; H302; H314; H330
    Caution Statement P210; P260; P280; P304 + P340 + P310; P305 + P351 + P338; P370 + P378
    Signal Word Danger
    Symbol GHS02, GHS05, GHS06
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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name Acetic anhydride

    1.2 Other means of identification

    Product number -
    Other names Acetic acid, anhydride

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 3

    Acute toxicity - Oral, Category 4

    Skin corrosion, Category 1B

    Acute toxicity - Inhalation, Category 4

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H226 Flammable liquid and vapour

    H302 Harmful if swallowed

    H314 Causes severe skin burns and eye damage

    H332 Harmful if inhaled

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P310 Immediately call a POISON CENTER/doctor/…

    P321 Specific treatment (see ... on this label).

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Acetic anhydride Acetic anhydride 108-24-7 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Liquid is volatile and causes little irritation on uncovered skin. However, causes severe burns when clothing is wet with the chemical or if it enters gloves or shoes. Causes skin and eye burns and irritation of respiratory tract. Nausea and vomiting may develop after exposure. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Activated charcoal is not effective ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic acids and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    If material on fire or involved in fire: Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors.

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Irritating vapors are generated when heated. Behavior in Fire: Dangerous when exposed to heat or fire. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Consult an expert! Personal protection: chemical protection suit, face shield and filter respirator for acid gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT absorb in saw-dust or other combustible absorbents

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry.Store in cool, dry, well-ventilated location. Outside or detached storage is preferred. Store away from heat, oxidizers, and sunlight. Exclude moisture from vapor space in storage tanks.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    Recommended Exposure Limit: (15-Min) Ceiling value: 5 ppm (20 mg/cu m).

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Colorless liquid
    Colour Very refractive liquid
    Odour Strong acetic odor
    Melting point/ freezing point -73.1 °C
    Boiling point or initial boiling point and boiling range 138-140°C(lit.)
    Flammability Class II Combustible Liquid: Fl.P. at or above 37.78°C and below 60°C.Flammable.
    Lower and upper explosion limit / flammability limit Lower flammable limit: 2.7% by volume; Upper flammable limit: 10.3% by volume
    Flash point 49°C
    Auto-ignition temperature 331.67°C
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 0.843 mPa-s @ 25°C
    Solubility In water:REACTS
    Partition coefficient n-octanol/water (log value) -0.27
    Vapour pressure 10 mm Hg ( 36 °C)
    Density and/or relative density 1.08g/mL(lit.)
    Relative vapour density 3.5 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Volatile

    10.3 Possibility of hazardous reactions

    Moderate, when exposed to heat or flameACETIC ANHYDRIDE reacts violently on contact with water, steam, methanol, ethanol, glycerol and boric acid. Reaction with water is particularly dangerous in presence with mineral acids (e.g., nitric, perchloric, chromic, sulfuric acid) [Chem. Eng. News 25, 3458]. Potentially explosive reactions with oxidizing reagents such as barium peroxide, chromium trioxide, chromic acid, hypochlorous acid, nitric acid, perchloric acid, peroxyacetic acid, potassium permanganate, hydrogen peroxide. [Sax, 9th ed., 1996, p. 15]. Reacts violently with metal nitrates used as nitrating agents [Davey W. et al., Chem. & Ind., 1948, p. 814].

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Mixing acetic anhydride with /each of the following chemicals individually/ in a closed container caused the temperature and pressure to increase: 2-aminoethanol; aniline; chlorosulfonic acid; and ethylene diamine, ethyleneimine; 36% hydrochloric acid; 48.7% hydrofluoric acid; 70% nitric acid; oleum and sodium hydroxide

    10.6 Hazardous decomposition products

    When heated to decomposition it emits toxic fumes.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 1780 mg/kg
    • Inhalation: LC50 Rat inhalation 1680 mg/cu m 6 hr
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    TLV-A4

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: no data available
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    no data available

    12.3 Bioaccumulative potential

    The half-life for the hydrolysis of acetic anhydride is 4.4 minutes(SRC), based on a rate constant of 0.002625 1/sec at 25°C(1). Bioconcentration of acetic anhydride in aquatic organisms is unlikely due its rapid hydrolysis(SRC).

    12.4 Mobility in soil

    The half-life for the hydrolysis of acetic anhydride is 4.4 minutes(SRC), based on a rate constant of 0.002625 1/sec at 25°C(1). Hydrolysis is expected to be the predominate fate of acetic anhydride in soil(SRC).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1715 IMDG: UN1715 IATA: UN1715

    14.2 UN Proper Shipping Name

    ADR/RID: ACETIC ANHYDRIDE
    IMDG: ACETIC ANHYDRIDE
    IATA: ACETIC ANHYDRIDE

    14.3 Transport hazard class(es)

    ADR/RID: 3 IMDG: 3 IATA: 3

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Acetic anhydride Acetic anhydride 108-24-7 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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