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    tetrachloromethane
    CAS No.: 56-23-5 Formula: CCl4 Molecular Weight: 153.82300
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    tetrachloromethane

    CAS No.: 56-23-5 Formula: CCl4 Molecular Weight: 153.82300
    Suppliers: All (60) China Suppliers (60) Price Available (13) Contractor (1)

    Description

    Carbon Tetrachloride is used in biological studies to evaluate the genotoxicity and toxicity in primary hepatocyte culture of humans and lab animals.

    Numbering system

    UNII CL2T97X0V0

    Properties

    Appearance & Physical State clear colorless liquid
    Density 1.594
    Boiling Point 76oC
    Melting Point -23oC
    Flash Point Use any means suitable for fire extinguisher
    Refractive Index 1.459-1.46
    Water Solubility 0.8 g/L (20 oC)
    Storage Condition 2-8oC
    Vapor Density 5.32 (vs air)
    Vapor Pressure 4.05 psi ( 20 °C)

    Safety Info

    RTECS FG4900000
    Hazard Class 6.1(a)
    Safety Statements S23-S36/37-S45-S59-S61
    HS Code 2903140090
    WGK Germany 3
    Packing Group II
    RIDADR UN 1846
    Risk Statements R23/24/25; R40; R48/23; R52/53; R59
    Hazard Codes T; N
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 17, 2017

    Revision Date: Aug 17, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name tetrachloromethane

    1.2 Other means of identification

    Product number -
    Other names tert-butyl N-acetate

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Volatile organic compounds
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 3

    Acute toxicity - Dermal, Category 3

    Acute toxicity - Inhalation, Category 3

    Carcinogenicity, Category 2

    Specific target organ toxicity – repeated exposure, Category 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

    Hazardous to the ozone layer, Category 1

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H311 Toxic in contact with skin

    H331 Toxic if inhaled

    H351 Suspected of causing cancer

    H372 Causes damage to organs through prolonged or repeated exposure

    H412 Harmful to aquatic life with long lasting effects

    H420 Harms public health and the environment by destroying ozone in the upper atmosphere

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P201 Obtain special instructions before use.

    P202 Do not handle until all safety precautions have been read and understood.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    Response

    P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P311 Call a POISON CENTER/doctor/…

    P308+P313 IF exposed or concerned: Get medical advice/ attention.

    P314 Get medical advice/attention if you feel unwell.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to ...

    P502 Refer to manufacturer or supplier for information on recovery or recycling

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    tetrachloromethane tetrachloromethane 56-23-5 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Dizziness, incoordination, anesthesia; may be accompanied by nausea and liver damage. Kidney damage also occurs, often producing decrease or stopping of urinary output. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Irrigate eyes with water. Wash contaminated areas of body with soap and water. Gastric lavage, if swallowed, followed by saline catharsis. Oxygen and artificial respiration.

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    When fighting a fire in which carbon tetrachloride is involved, wear self-contained breathing apparatus.

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Forms poisonous phosgene gas when exposed to open flames. Behavior in Fire: Decomposes to form chlorine and phosgene (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    1. VENTILATE AREA OF SPILL OR LEAK. 2. COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from food and feedstuffs and metals. See Chemical Dangers. Ventilation along the floor. Cool.Store in a cool, dry, well-ventilated location. Separate from alkali metals.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    Recommended Exposure Limit: 60 Min Short-Term Exposure Limit: 2 ppm, 12.6 mg/cu m

    NIOSH has recommended that carbon tetrachloride be treated as a potential human carcinogen.

    NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concn.

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state clear colorless liquid
    Colour Colorless, clear, heavy liquid
    Odour SWEETISH, AROMATIC, MODERATELY STRONG ETHEREAL; SOMEWHAT RESEMBLING THAT OF CHLOROFORM
    Melting point/ freezing point -23oC
    Boiling point or initial boiling point and boiling range 76oC
    Flammability Noncombustible LiquidNot combustible. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit no data available
    Flash point Use any means suitable for fire extinguisher
    Auto-ignition temperature Not flammable (USCG, 1999)
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 2.03X10-3 Pa.s @ 250.00 K
    Solubility In water:0.8 g/L (20 oC)
    Partition coefficient n-octanol/water (log value) log Kow= 2.83
    Vapour pressure 4.05 psi ( 20 °C)
    Density and/or relative density 1.594
    Relative vapour density 5.32 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    ... Generally inert ...

    10.3 Possibility of hazardous reactions

    Not flammableThe vapour is heavier than air.CARBON TETRACHLORIDE is a commonly used liquid in fire extinguishers to combat small fires. It has no flash point, it is not flammable. However, when heated to decomposition, it will emit fumes of extremely toxic phosgene and of hydrogen chloride. Forms explosive mixtures with chlorine trifluoride, calcium hypochlorite, decaborane, dinitrogen tetraoxide, fluorine. Forms impact-sensitive explosive mixtures with particles of many metals: lithium, sodium, potassium, beryllium, zinc, aluminum, barium. Vigorous exothermic reaction with allyl alcohol, boron trifluoride, diborane, disilane, aluminum chloride, dibenzoyl peroxide, potassium tert-butoxide, liquid oxygen, zirconium. [Bretherick, 5th ed., 1995, p. 666]. Potentially dangerous reaction with dimethylformamide or dimethylacetamide in presence of iron [Cardillo, P. et al., Ann. Chim. (Rome), 1984, 74, p. 129].

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    A paste of zinc powder and carbon tetrachloride (with kieselguhr as thickener) will readily burn after ignition by a high-temperature primer.

    10.6 Hazardous decomposition products

    Decomposes to form chlorine and phosgene.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 2920 mg/kg
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    NTP: Reasonably anticipated to be a human carcinogen

    Reproductive toxicity

    No information is available on the reproductive effects of carbon tetrachloride in humans. Limited epidemiological data have indicated a possible association between certain birth outcomes (e.g., birth weight, cleft palate) and drinking water exposure. However, as the water contained multiple chemicals, the role of carbon tetrachloride is unclear. Decreased fertility and degenerative changes in the testes have been observed in animals exposed to carbon tetrachloride by inhalation. Birth defects have not been observed in animals exposed to carbon tetrachloride by inhalation or ingestion.

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 125,000 ug/l/96 hr (static unmeasured)
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: The static screening flask test method measured >87% degradation of carbon tetrachloride in 7 days in the original test, and 100% degradation in the second, third, and fourth trials(1). In a standard dilution test, 0% Theoretical BOD for carbon tetrachloride was measured(2).

    12.3 Bioaccumulative potential

    A BCF of 3.2-7.4 for carbon tetrachloride was measured(1). A measured BCF value for trout, rainbow trout and bluegill sunfish was found to be 17.37(2,3), 52.48(5), and 30.2(4) and 26.3(5), respectively. According to a classification scheme(6), these BCF values suggest the potential for bioconcentration in aquatic organisms is low.

    12.4 Mobility in soil

    The Koc for carbon tetrachloride was measured to be 71(1). According to a classification scheme(4), this Koc value suggests that carbon tetrachloride is expected to have high mobility in soil. Estimated retardation factor in breakthrough sampling in groundwater - 1.44-1.8(2,3).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1846 IMDG: UN1846 IATA: UN1846

    14.2 UN Proper Shipping Name

    ADR/RID: CARBON TETRACHLORIDE
    IMDG: CARBON TETRACHLORIDE
    IATA: CARBON TETRACHLORIDE

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    tetrachloromethane tetrachloromethane 56-23-5 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 17, 2017
    Revision Date Aug 17, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    13C NMR : in CDCl3Expand

    NMR Spectrum 13C NMR : in CDCl3

    Collapse

    C Cl4 0.5 ml : 1.5 ml CDCl3
    tetrachloromethane

    ppm Int. Assign.
    96.09 1000 1

    IR : liquid filmExpand
    Mass Expand
    Raman : 4880 A,100M,liquidExpand
    ESR : PHOTOLYSIS OF (CH3)3SIH/DTBPO IN CCL4Expand
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