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    4-Bromoaniline
    CAS No.: 106-40-1 Formula: C6H6BrN Molecular Weight: 172.02300
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    4-Bromoaniline

    CAS No.: 106-40-1 Formula: C6H6BrN Molecular Weight: 172.02300
    Suppliers: All (85) China Suppliers (85) Price Available (17) Contractor (5)

    Description

    4-Bromoaniline is a compound where an aniline molecule is substituted with a bromine atom. Commercially available, this compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction.

    Numbering system

    EINECS number 203-393-9
    BRN number 742031
    MDL number MFCD00007822
    RTECS number BW9280000

    Properties

    Appearance & Physical State crystalline
    Density 1.5
    Boiling Point 225.9oC at 760 mmHg
    Melting Point 60-64oC
    Flash Point 90.4oC
    Refractive Index 1.5835 (99.6oC)
    Stability Stable. Combustible. Incompatible with strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, chloroformates. May be air sensitive.
    Storage Condition Store in a cool place in the original container and protect from sunlight. Store in a tightly closed container.
    Vapor Pressure 0.0843mmHg at 25°C

    Safety Info

    RTECS BW9280000
    Hazard Class 6.1
    Safety Statements S26-S36/37/39
    HS Code 29214210
    WGK Germany 3
    Packing Group III
    RIDADR UN 2811 6.1/PG 3
    Risk Statements R20/21/22; R36/37/38
    Hazard Codes Xn
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 10, 2017

    Revision Date: Aug 10, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name 4-Bromoaniline

    1.2 Other means of identification

    Product number -
    Other names para bromo aniline

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only.
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    Acute toxicity - Dermal, Category 3

    Skin irritation, Category 2

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H302 Harmful if swallowed

    H311 Toxic in contact with skin

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P321 Specific treatment (see ... on this label).

    P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

    P332+P313 If skin irritation occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P337+P313 If eye irritation persists: Get medical advice/attention.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    4-Bromoaniline 4-Bromoaniline 106-40-1 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Refer for medical attention.

    In case of skin contact

    Rinse and then wash skin with water and soap.

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    SYMPTOMS: Symptoms of exposure to this compound may include cyanosis (blue-black lips and tongue; gray skin) due to methemoglobinemia, headache, nausea and vomiting, dry throat, confusion, dizziness, tinnitus, weakness, irritability, drowsiness, coma, seizures, hypotension, fainting, joint pains, hemolytic anemia, jaundice, hepatic and renal damage, and bloody urine. ACUTE/CHRONIC HAZARDS: This compound can be absorbed through the skin. When heated to decomposition it emits toxic fumes.

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aniline and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Special protective equipment for firefighters Wear self contained breathing apparatus for fire fighting if necessary.

    5.2 Specific hazards arising from the chemical

    Flash point data are not available for this chemical, but it is probably combustible.

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment.

    6.3 Methods and materials for containment and cleaning up

    Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from strong oxidants and acids. Well closed.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Air sensitive.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state crystalline
    Colour Bipyramidal rhombic crystals, needles from 60% alcohol
    Odour no data available
    Melting point/ freezing point -9°C(lit.)
    Boiling point or initial boiling point and boiling range 124°C/14mmHg(lit.)
    Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit no data available
    Flash point 78°C(lit.)
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility less than 1 mg/mL at 22.78°C
    Partition coefficient n-octanol/water (log value) log Kow = 2.26
    Vapour pressure 0.0843mmHg at 25°C
    Density and/or relative density 1.5
    Relative vapour density 5.9 (Air = 1)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    Vapor may form highly reactive mixtures in air.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    The solution in water is a weak base. Reacts with acids and strong oxidants.

    10.6 Hazardous decomposition products

    Decomposes on heating and on burning. This produces toxic and corrosive fumes including hydrogen bromide and nitrogen oxides.

    11.Toxicological information

    Acute toxicity

    • Oral: no data available
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead Minnow) age 26-34 day juvenile; Conditions: freshwater, flow through, 25°C, pH 7.8, hardness 45 mg/L CaCO3, alkalinity 42 mg/L CaCO3; Concentration: 47500 ug/L for 96 hr /> or =95% purity
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: Soil enrichment cultures extracted from soils that had been treated with herbicides (such as linuron and metobromuron) over multiple years were able to readily degrade the herbicides and their degradation products (4-bromoaniline was the degradation product from metobromuron)(1); untreated control soil samples from the same location did not show any degradation activity(1). In biodegradation studies using Elbe River water and a testfilter methodology, 4-bromoaniline had a mean degradation rate of 0.67/hr (half-life of about 1 hour)(2); degradation rate in control samples was only 0.007/hr (half-life of 99 hours)(2).

    12.3 Bioaccumulative potential

    An estimated BCF of 14 was calculated in fish for 4-bromoaniline(SRC), using a log Kow of 2.26(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    Soil adsorption studies using four silt loam soils and a 2-hour adsorption period determined a mean log Kom (K organic matter) of 1.72 (which corresponds to a log Koc of 1.96 and Koc of 91 for 4-bromoaniline(1). A Koc of 217.9 was determined in sorption studies using a calcareous Spanish soil(2); manual addition of dissolved organic carbon (from peat or tannic acid) was found to increase 4-bromoanline adsorption on soil(2). According to a classification scheme(3), these Koc values suggests that 4-bromoaniline is expected to have moderate to high mobility in soil. The pKa of 4-bromoaniline is 3.86(4), indicating that this compound is a weak base and will exist predominantly in the non-ionized form in the environment. However, anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(5,6), suggesting that mobility may be much lower in some soils(SRC).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1325 IMDG: UN1325 IATA: UN1325

    14.2 UN Proper Shipping Name

    ADR/RID: FLAMMABLE SOLID, ORGANIC, N.O.S.
    IMDG: FLAMMABLE SOLID, ORGANIC, N.O.S.
    IATA: FLAMMABLE SOLID, ORGANIC, N.O.S.

    14.3 Transport hazard class(es)

    ADR/RID: 4.1 IMDG: 4.1 IATA: 4.1

    14.4 Packing group, if applicable

    ADR/RID: III IMDG: III IATA: III

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    4-Bromoaniline 4-Bromoaniline 106-40-1 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 10, 2017
    Revision Date Aug 10, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C6 H6 Br N 0.048 g : 0.5 ml CDCl3
    p-bromoaniline

    Assign. Shift(ppm)
    A 7.214
    B 6.542
    C 3.35

    IR : KBr discExpand
    Mass Expand
    Raman : 4880 A,200 M,powderExpand

    GC Analysis

    Total 3 Documents >>
    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Capillary TR-1 - 1248. temperature ramp
    Capillary TR-1 - 1248. temperature ramp
    Capillary Ultra-1 - 1245. temperature ramp
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