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    1,2-phenylenediamine
    CAS No.: 95-54-5 Formula: C6H8N2 Molecular Weight: 108.14100
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    1,2-phenylenediamine

    CAS No.: 95-54-5 Formula: C6H8N2 Molecular Weight: 108.14100
    Suppliers: All (95) China Suppliers (95) Price Available (19) Contractor (9)

    Description

    o-Phenylenediamine is an organic compound with the formula C6H4(NH2)2. This aromatic diamine is an important precursor to many heterocyclic compounds. It is isomeric with m-phenylenediamine and p-phenylenediamine, and is commonly referred to as OPD.

    Basic Info

    Chemical Name 1,2-phenylenediamine
    Synonyms

    ik3; 1,2-Benzenediamine; ortho-phenylenediamine; PODA; 1.2-diaminobenzene; OPDA; ortho-benzenediamine; ek1700; o-Phenylenediamine; OPD; ortho-diaminobenzene; Expand

    CAS No. 95-54-5
    Molecular Formula C6H8N2
    Molecular Weight 108.14100
    PSA 52.04000
    LogP 2.01340

    Numbering system

    MDL number MFCD00007721
    EINECS number 202-430-6

    Properties

    Appearance & Physical State brown yellow, red brown or brown crystals
    Density 1.27
    Boiling Point 257oC
    Melting Point 101oC
    Flash Point 110oC
    Refractive Index 1.66
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8oC
    Vapor Density 3.7 (vs air)
    Vapor Pressure 0.01 mm Hg ( 25 °C)

    Safety Info

    RTECS SS7875000
    Hazard Class 6.1
    Safety Statements S1/2-S28-S36/37-S45-S60-S61
    HS Code 29215119
    WGK Germany 3
    Packing Group III
    RIDADR UN 1673
    Risk Statements R20/21; R36; R40; R43; R50/53; R68
    Hazard Codes T; N
    Caution Statement P261; P280; P305 + P351 + P338
    Symbol GHS06, GHS08, GHS09
    Signal Word Danger
    Hazard Declaration H301; H312 + H332; H317; H319; H341; H351; H410
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name 1,2-phenylenediamine

    1.2 Other means of identification

    Product number -
    Other names ik3

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 3

    Acute toxicity - Dermal, Category 4

    Eye irritation, Category 2

    Skin sensitization, Category 1

    Acute toxicity - Inhalation, Category 4

    Germ cell mutagenicity, Category 2

    Carcinogenicity, Category 2

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H312 Harmful in contact with skin

    H319 Causes serious eye irritation

    H317 May cause an allergic skin reaction

    H332 Harmful if inhaled

    H341 Suspected of causing genetic defects

    H351 Suspected of causing cancer

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P271 Use only outdoors or in a well-ventilated area.

    P201 Obtain special instructions before use.

    P202 Do not handle until all safety precautions have been read and understood.

    P273 Avoid release to the environment.

    Response

    P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P337+P313 If eye irritation persists: Get medical advice/attention.

    P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P308+P313 IF exposed or concerned: Get medical advice/ attention.

    P391 Collect spillage.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    1,2-phenylenediamine 1,2-phenylenediamine 95-54-5 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse and then wash skin with water and soap.

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    SYMPTOMS: Symptoms of exposure to this chemical may include skin and eye irritation, headache, drowsiness, mental confusion and liver damage. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. It is highly toxic by inhalation and skin absorption.

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Use water spray, powder.

    5.2 Specific hazards arising from the chemical

    Flash point data for this chemical are not available. It is probably combustible.

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

    6.3 Methods and materials for containment and cleaning up

    Spillage Disposal. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do not let this chemical enter the environment. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from food and feedstuffs. Well closed.Separated from food and feedstuffs. Well closed.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state brown yellow, red brown or brown crystals
    Colour Brownish-yellow leaflets from water; plates from chloroform
    Odour no data available
    Melting point/ freezing point 150°C(lit.)
    Boiling point or initial boiling point and boiling range 256-258°C
    Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit Lower flammable limit: 1.5%
    Flash point 136°C
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility less than 1 mg/mL at 20°C
    Partition coefficient n-octanol/water (log value) log Kow = 0.15
    Vapour pressure 0.01 mm Hg ( 25 °C)
    Density and/or relative density 1.27
    Relative vapour density 3.7 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    Dust explosion possible if in powder or granular form, mixed with air.1,2-PHENYLENEDIAMINE a weak aromatic amine base neutralizes acids in exothermic reactions to form salts. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Darkens on exposure to air (Roger Patrick, DuPont Engineer).

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    STABILITY: This compound darkens on exposure to air. It is also sensitive to light. Solutions of this chemical should be stable for 24 hours under normal lab conditions.

    10.6 Hazardous decomposition products

    When heated to decomp, it emits toxic fumes of /nitrogen oxides/.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 660-1284 mg/kg, females more sensitive than males.
    • Inhalation: LC50 Mouse inhalation > 91 mg/cu m/4H
    • Dermal: LD50 Rat percutaneous (24 hours) > 5000 mg/kg

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    A3; Confirmed animal carcinogen with unknown relevance to humans.

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Brachydanio rerio (Zebrafish); Concentration: 24 mg/L for 96 hr /Conditions of bioassay not specified
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: In an aerobic screening study using acclimated activated sludge inoculum, o-phenylenediamine (initial concentration of 25 to 30 ppm) exhibited 33% removal after 5 days incubation(1). In a screening test using soil microflora and an initial concentration of 10 ug/mL o-phenylenediamine, the decomposition period was observed to be >64 days for total loss of ultraviolet absorbency at a wavelength of 294 nm(2). o-Phenylenediamine (initial concentration of 500 ppm) exhibited a 44.5% theoretical BOD after 8 days in a Warburg respirometer using aniline-acclimated sludge at 20°C(3). o-Phenylenediamine, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(4).

    12.3 Bioaccumulative potential

    An estimated BCF of 3 was calculated in fish for o-phenylenediamine(SRC), using a log Kow of 0.15(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc of o-phenylenediamine can be estimated to be 34(SRC). According to a classification scheme(2), this estimated Koc value suggests that o-phenylenediamine is expected to have very high mobility in soil. However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1673 IMDG: UN1673 IATA: UN1673

    14.2 UN Proper Shipping Name

    ADR/RID: PHENYLENEDIAMINES (o-, m-, p-)
    IMDG: PHENYLENEDIAMINES (o-, m-, p-)
    IATA: PHENYLENEDIAMINES (o-, m-, p-)

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable

    ADR/RID: III IMDG: III IATA: III

    14.5 Environmental hazards

    ADR/RID: yes IMDG: yes IATA: yes

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    1,2-phenylenediamine 1,2-phenylenediamine 95-54-5 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 400 MHz in DMSO-d6Expand

    NMR Spectrum 1H NMR : 400 MHz in DMSO-d6

    Collapse

    C6 H8 N2 0.040 g : 0.5 ml DMSO-d6
    o-phenylenediamine

    Assign. Shift(ppm)
    A 6.504
    B 6.382
    C 4.36

    IR : liquid filmExpand
    Mass spectrum (electron ionization)Expand
    UV/Visible spectrumExpand
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