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    Benzene
    CAS No.: 71-43-2 Formula: C6H6 Molecular Weight: 78.11180
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    Benzene

    CAS No.: 71-43-2 Formula: C6H6 Molecular Weight: 78.11180
    Suppliers: All (95) China Suppliers (95) Price Available (12) Contractor (16)

    Description

    Benzene is a natural constituent of crude oil, and is one of the most elementary petrochemicals. It is used mainly as an intermediate to make other chemicals. About 80% of benzene is consumed in the production of three chemicals, ethylbenzene, cumene, and cyclohexane. As a gasoline (petrol) additive, benzene increases the octane rating and reduces knocking.

    Basic Info

    Chemical Name Benzene
    Synonyms

    Phene; Benzole; Benzolo; Benzen; Annulene; Fenzen; Benzeen; [6]Annulene (not recommended); Benzol (historic/German); Cyclohexa-1,3,5-triene; 1,3,5-Cyclohexatriene; Expand

    CAS No. 71-43-2
    Molecular Formula C6H6
    Molecular Weight 78.11180
    PSA 0.00000
    LogP 1.68660

    Numbering system

    UNII J64922108F

    Properties

    Appearance & Physical State clear colorless liquid with a petroleum-like odor
    Density 0.8786
    Boiling Point 80oC
    Melting Point 5.5oC
    Flash Point -11oC
    Refractive Index 1.5011
    Water Solubility 0.18 g/100 mL
    Stability Stable. Substances to be avoided include strong oxidizing agents, sulfuric acid, nitric acid, halogens. Highly flammable.
    Storage Condition 0-6oC
    Vapor Density 2.77 (vs air)
    Vapor Pressure 166 mm Hg ( 37.7 °C)

    Safety Info

    RTECS CY1400000
    Hazard Class 3
    Safety Statements S53-S45
    HS Code 2707100000
    Packing Group II
    WGK Germany 3
    RIDADR UN 1114 3/PG 2
    Risk Statements R45; R46; R11; R36/38; R48/23/24/25; R65
    Hazard Codes F
    Hazard Declaration H225; H304; H315; H319; H340; H350; H372; H412
    Symbol GHS02, GHS07, GHS08
    Caution Statement P201; P210; P280; P308 + P313; P370 + P378; P403 + P235
    Signal Word Danger
    SDS 1.0 Expand

    SDS 1.0

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    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name benzene

    1.2 Other means of identification

    Product number -
    Other names Benzole

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Hydrocarbons (contain hydrogen and carbon atoms), Volatile organic compounds
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 2

    Skin irritation, Category 2

    Eye irritation, Category 2

    Aspiration hazard, Category 1

    Germ cell mutagenicity, Category 1B

    Carcinogenicity, Category 1A

    Specific target organ toxicity – repeated exposure, Category 1

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H304 May be fatal if swallowed and enters airways

    H340 May cause genetic defects

    H350 May cause cancer

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    P201 Obtain special instructions before use.

    P202 Do not handle until all safety precautions have been read and understood.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P321 Specific treatment (see ... on this label).

    P332+P313 If skin irritation occurs: Get medical advice/attention.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P337+P313 If eye irritation persists: Get medical advice/attention.

    P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

    P331 Do NOT induce vomiting.

    P308+P313 IF exposed or concerned: Get medical advice/ attention.

    P314 Get medical advice/attention if you feel unwell.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    benzene benzene 71-43-2 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Dizziness, excitation, pallor, followed by flushing, weakness, headache, breathlessness, chest constriction, nausea, and vomiting. Coma and possible death. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Benzene and Related Compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Approach fire from upwind to avoid hazardous vapors. Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.

    5.2 Specific hazards arising from the chemical

    Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    For spills on water, contain with booms or barriers, use surface acting agents to thicken spilled materials. Remove trapped materials with suction hoses.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from food and feedstuffs, oxidants and halogens. Store in an area without drain or sewer access.Keep in well closed containers in a cool place and away from fire.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

    Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.1 ppm.

    Recommended Exposure Limit: 15 Minute Short-Term Exposure Limit: 1 ppm.

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state clear colorless liquid with a petroleum-like odor
    Colour Clear, colorless liquid
    Odour Aromatic odor
    Melting point/ freezing point -11°C(lit.)
    Boiling point or initial boiling point and boiling range 80°C(lit.)
    Flammability Highly flammable.
    Lower and upper explosion limit / flammability limit Lower flammable limit: 1.2% by volume; Upper flammable limit: 7.8% by volume
    Flash point -11°C
    Auto-ignition temperature 561.67°C
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 0.604 mPa.s at 25°C
    Solubility In water:0.18 g/100 mL
    Partition coefficient n-octanol/water (log value) log Kow = 2.13
    Vapour pressure 166 mm Hg ( 37.7 °C)
    Density and/or relative density 0.874g/mLat 25°C(lit.)
    Relative vapour density 2.77 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    A dangerous fire hazard when exosed to heat or flame. ... Ignites on contact with sodium peroxide + water, dioxygenyl tetrafluoroborate, iodine heptafluoride, and dioxygen difluoride.The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.Benzene vapors are heavier than air. They will spread along the ground and collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.Benzene liquid is less dense than water and will float on the surface of water.BENZENE reacts vigorously with allyl chloride or other alkyl halides even at -70° C in the presence of ethyl aluminum dichloride or ethyl aluminum sesquichloride. Explosions have been reported [NFPA 491M 1991]. Ignites in contact with powdered chromic anhydride [Mellor 11:235 1946-47]. Incompatible with oxidizing agents such as nitric acid. Mixtures with bromine trifluoride, bromine pentafluoride, iodine pentafluoride, iodine heptafluoride and other interhalogens can ignite upon heating [Bretherick 5th ed. 1995]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.). The reaction of benzene and trichloroacetonitrile evolves toxic chloroform and HCl gases. (Hagedorn, F., H.-P. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Reacts violently with iodine pentafluoride.

    10.6 Hazardous decomposition products

    no data available

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 3306 mg/kg
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    NTP: Known to be a human carcinogen. EPA: Known human carcinogen. IARC: Carcinogenic to humans

    Reproductive toxicity

    There is some evidence from human epidemiological studies of reproductive and developmental toxicity of benzene, however the data do not provide conclusive evidence of a link between exposure and effect (4). Animal studies have provided limited evidence that exposure to benzene may affect reproductive organs, however these effects were only observed at exposure levels over the maximum tolerated dose . Adverse effects on the fetus, including low birth weight, delayed bone formation, and bone marrow damage, have been observed where pregnant animals were exposed to benzene by inhalation.

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Salmo trutta (brown trout) yearlings; Conditions: static bioassay; Concentration: 12 mg/L for 1 hr
    • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static, 20°C, pH 8.2, hardness 130 mg/L CaCO3; Concentration: 18000 ug/L for 24 hr (95% confidence interval: 14810-21900 ug/L); Effect: intoxication, immobilization />99.7% purity
    • Toxicity to algae: EC50; Species: Chlorella vulgaris (Green Algae); Conditions: freshwater, static, 20°C; Concentration: 525000 ug/L for 24 hr; Effect: growth, general /formulation
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: Benzene present at 100 mg/L, reached 40% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Benzene reached 24% of its theoretical oxygen demand in a non-acclimated microbial population after 15 days(2). Aerobic biodegradation of benzene was studied in pre-equilibrated soil-water slurry microcosms(3). Using an enriched aerobic bacterial culture, benzene began to degrade 12 hrs after incubation in an aqueous(soil-free) solution with 50% of benzene degrading after 60 hrs and almost complete degradation within 90 hrs. Using a pre-equilibrated soil-water slurry microcosm, benzene did not begin to degrade until 3 days after application and reached complete degradation after about 12 days(3).

    12.3 Bioaccumulative potential

    Benzene has BCFs ranging from 1.1-20(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is low. The uptake and elimination rate constants for benzene in fathead minnows were studied(3). Fathead minnows were found to have an average uptake rate of 7 L/kg/hr with an average elimination rate of 0.384/hr which corresponds to a BCF of 19(3). In a study of BCF values for various aquatic species, benzene was found to have a BCF value of 3.5 in eels(4), 4.4 in pacific herring(5), and 4.3 in goldfish(6).

    12.4 Mobility in soil

    An experimentally derived log Koc of 1.93 (Koc = 85) was obtained via reverse phase HPLC (high performance liquid chromatography) with a cyanopropyl column and a mobile phase of water(1). According to a classification scheme(2), this estimated Koc value suggests that benzene is expected to have high mobility in soil. The sorption equilibrium for benzene in a soil/water mixture (ratio soil/water 0.12 kg/l) took 72 hrs(3). The Koc for benzene has also been experimentally determined to be 79(4).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1114 IMDG: UN1114 IATA: UN1114

    14.2 UN Proper Shipping Name

    ADR/RID: BENZENE
    IMDG: BENZENE
    IATA: BENZENE

    14.3 Transport hazard class(es)

    ADR/RID: 3 IMDG: 3 IATA: 3

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    benzene benzene 71-43-2 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : parameter in CDCl3Expand

    NMR Spectrum 1H NMR : parameter in CDCl3

    Collapse

    C6 H6 0.04 ml : 0.5 ml CDCl3
    benzene

    Parameter ppm Hz
    D(A) 7.339

    IR : liquid filmExpand
    Mass Expand
    Raman : 4880 A,100M,liquidExpand
    ESR : ANION RADICAL, REDUCTION WITH K-NA IN THF-DMEExpand
    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Administration onto the skin Open irritation test Rodent - rabbit 15 mg/24H -
    Administration onto the skin Standard Draize test Rodent - rabbit 20 mg/24H -
    Administration into the eye Standard Draize test Rodent - rabbit 88 mg -
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