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    Diethylene glycol
    CAS No.: 111-46-6 Formula: C4H10O3 Molecular Weight: 106.12000
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    Diethylene glycol

    CAS No.: 111-46-6 Formula: C4H10O3 Molecular Weight: 106.12000
    Suppliers: All (284) China Suppliers (187) Price Available (25) Contractor (24)

    Description

    Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. DEG is a widely used solvent. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century.

    Basic Info

    Chemical Name Diethylene glycol
    Synonyms

    Ethanol, 2,2‘-oxybis-; 2,2'-Oxydiethanol; DEG; Bis(2-hydroxyethyl)ether;

    CAS No. 111-46-6
    Molecular Formula C4H10O3
    Molecular Weight 106.12000
    PSA 49.69000
    LogP -1.01240

    Numbering system

    RTECS number ID5950000
    MDL number MFCD00002882
    BRN number 969209
    EINECS number 203-872-2
    PubChem number 24889810

    Properties

    Appearance & Physical State Clear liquid
    Density 1.11
    Boiling Point 245oC
    Melting Point -10oC
    Freezing Point -10.45℃
    Flash Point 143oC
    Refractive Index 1.445-1.448
    Water Solubility SOLUBLE
    Stability Stable under normal temperatures and pressures.
    Storage Condition Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store protected from moisture.
    Vapor Density 2.14 (vs air)
    Vapor Pressure 0.01 mm Hg ( 20 °C)

    Safety Info

    RTECS ID5950000
    Safety Statements S46
    HS Code 2909410000
    WGK Germany 1
    Risk Statements R22
    Hazard Codes Xn
    Symbol GHS07, GHS08
    Hazard Declaration H302; H373
    Signal Word Warning
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 10, 2017

    Revision Date: Aug 10, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name Diethylene glycol

    1.2 Other means of identification

    Product number -
    Other names 2,2'-Oxydiethanol

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Food Additives: CARRIER_SOLVENT
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Diethylene glycol Diethylene glycol 111-46-6 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest.

    In case of skin contact

    Rinse skin with plenty of water or shower.

    In case of eye contact

    Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

    If swallowed

    Give one or two glasses of water to drink. Rinse mouth. Refer immediately for medical attention. See Notes.

    4.2 Most important symptoms/effects, acute and delayed

    Ingestion of large amounts may cause degeneration of kidney and liver and cause death. Liquid may cause slight skin irritation. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Supportive Care: The patient should be resuscitated with isotonic crystalloidal fluids, and acidosis should be corrected. Early treatment with a competitive ADH inhibitor (e.g., 4-methylpyrazole or ethanol), hemodialysis, and supportive care offer the best hope for patient recovery.

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Alcohol foam, water, carbon dioxide, dry chemical

    5.2 Specific hazards arising from the chemical

    This chemical is combustible.

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

    6.3 Methods and materials for containment and cleaning up

    SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Dry. Well closed. Separated from strong oxidants.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Clear liquid
    Colour Colorless syrupy liquid
    Odour Practically odorless
    Melting point/ freezing point -7°C(lit.)
    Boiling point or initial boiling point and boiling range 245°C(lit.)
    Flammability Combustible.
    Lower and upper explosion limit / flammability limit 1.6%-10.8%
    Flash point 143°C
    Auto-ignition temperature 227.78°C
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 0.30 cP at 25°C
    Solubility In water:SOLUBLE
    Partition coefficient n-octanol/water (log value) log Kow = -1.47 (est)
    Vapour pressure 0.01 mm Hg ( 20 °C)
    Density and/or relative density 1.116g/mLat 20°C
    Relative vapour density 2.14 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Low volatility

    10.3 Possibility of hazardous reactions

    Slight, when exposed to heat or flame; can react with oxidizing materials.DIETHYLENE GLYCOL is incompatible with strong oxidizing agents. It is also incompatible with strong bases. It can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. Mixtures with sodium hydroxide decompose exothermically when heated to 230°C.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    ... Can react with oxidizing materials ... Mixtures with sodium hydroxide decompose exothermically when heated to 230°C and release explosive hydrogen gas.

    10.6 Hazardous decomposition products

    When heated to decomposition it emits acrid smoke and irritating fumes.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 15.6 g/kg
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill fish); Conditions: static bioassay, filtered tap water, temperature 20°C; Concentration: 1,000 mg/L for 96 hours.
    • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, age < or =24 hr); Conditions: freshwater, static, 20-22°C, pH 7.6-7.7; Concentration: 10000000 ug/L for 24 hr /formulated product
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: Diethylene glycol, present at 30 mg/L, reached 90% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 100 mg/L in the Japanese MITI test(1). The compound, present at 100 mg/L, showed 59% (rate constant of 0.081/day, 5 day lag period) and 89% degradation (0.173/day, 5 day lag period) using the Sapromat and Oxitop systems, respectively, in manometric respirometry tests using activated sludge at 30 mg/L dry matter(2). Biodegradation of 44% and 78% degradation were reported when using seawater as inoculum in a shake flask die-away test (chemical concentration of 5-30 DOC/L) and the closed bottle oxygen consumption test (test chemical concentration of 2-10 mg/L), respectively, both incubated at 15-20°C for 28 to 60 days; however, high carbon levels may have compromised the test results(3).

    12.3 Bioaccumulative potential

    An estimated BCF of 3 was calculated in fish for diethylene glycol(SRC), using an estimated log Kow of -1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    Using a structure estimation method based on molecular connectivity indices(1), the Koc of diethylene glycol can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylene glycol is expected to have very high mobility in soil.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.2 UN Proper Shipping Name

    ADR/RID: unknown
    IMDG: unknown
    IATA: unknown

    14.3 Transport hazard class(es)

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.4 Packing group, if applicable

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Diethylene glycol Diethylene glycol 111-46-6 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Not Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 10, 2017
    Revision Date Aug 10, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C4 H10 O3 0.04 ml : 0.5 ml CDCl3
    2,2'-oxydiethanol

    Assign. Shift(ppm)
    A 4.47
    B 3.718
    C 3.596

    400MHZ : HSP-40-503

    IR : liquid filmExpand
    Mass Expand
    Raman : 4880 A,150M,liquidExpand

    GC Analysis

    Total 8 Documents >>
    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed Apiezon L 160. 927. isothermal
    Packed Apiezon L 170. 925. isothermal
    Packed PEG-2000 200. 1989. isothermal
    Capillary Ultra-2 - 967. temperature ramp
    Capillary Supelcowax-10 - 1975. temperature ramp
    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Administration onto the skin Standard Draize test Human 112 mg/3D (Intermittent) -
    Administration onto the skin Standard Draize test Rodent - rabbit 500 mg -
    Administration into the eye Standard Draize test Rodent - rabbit 50 mg -
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