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    Home >  Chemical Encyclopedia > Paints and Coatings > Inks > 2-Hydroxy-4-methoxybenzophenone
    2-Hydroxy-4-methoxybenzophenone
    CAS No.: 131-57-7 Formula: C14H12O3 Molecular Weight: 228.24300
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    2-Hydroxy-4-methoxybenzophenone

    CAS No.: 131-57-7 Formula: C14H12O3 Molecular Weight: 228.24300
    Suppliers: All (273) China Suppliers (173) Price Available (40) Contractor (26)

    Description

    Oxybenzone or benzophenone-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound. It is a pale-yellow solid that is readily soluble in most organic solvents. Oxybenzone belongs to the class of aromatic ketones known as benzophenones. It is a component of many sunscreen lotions.

    Basic Info

    Chemical Name 2-Hydroxy-4-methoxybenzophenone
    Synonyms

    Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-; Oxybenzone; Uvinul 3040; Benzophenone-3 (Bp-3); (2-Hydroxy-4-methoxyphenyl)(phenyl)methanone;

    CAS No. 131-57-7
    Molecular Formula C14H12O3
    Molecular Weight 228.24300
    PSA 46.53000
    LogP 2.63180

    Numbering system

    EINECS number 205-031-5
    BRN number 1913145
    PubChem number 24879471
    MDL number MFCD00008387
    RTECS number DJ1575000

    Properties

    Appearance & Physical State White to off-white or light yellow powder.
    Density 1.324
    Boiling Point 150-160oC (5 mmHg)
    Melting Point 62.5oC
    Flash Point 140.5oC
    Refractive Index 1.595
    Stability Stable under normal temperatures and pressures.
    Storage Condition Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
    Vapor Pressure 5.26E-06mmHg at 25°C

    Safety Info

    RTECS DJ1575000
    Hazard Class 4.1
    Safety Statements S26-S36
    HS Code 29145000
    Packing Group II; III
    WGK Germany 2
    Risk Statements R36/37/38
    Hazard Codes Xi
    Signal Word Warning
    Caution Statement P261; P305 + P351 + P338
    Hazard Declaration H315; H319; H335
    Symbol GHS07
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 10, 2017

    Revision Date: Aug 10, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name 2-Hydroxy-4-methoxybenzophenone

    1.2 Other means of identification

    Product number -
    Other names Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Processing aids, not otherwise listed
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H400 Very toxic to aquatic life

    H411 Toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    P391 Collect spillage.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    2-Hydroxy-4-methoxybenzophenone 2-Hydroxy-4-methoxybenzophenone 131-57-7 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

    In case of skin contact

    Wash off with soap and plenty of water. Consult a physician.

    In case of eye contact

    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

    If swallowed

    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

    4.2 Most important symptoms/effects, acute and delayed

    SYMPTOMS: Symptoms of exposure to this compound may include contact dermatitis and urticaria. It may also cause irritation. ACUTE/CHRONIC HAZARDS: This compound may cause irritation. When heated to decomposition it emits acrid smoke and irritating fumes.

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

    5.2 Specific hazards arising from the chemical

    Flash point data for this chemical are not available; however, it is probably combustible.

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

    6.3 Methods and materials for containment and cleaning up

    Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Store below 40°C (104 deg F), preferably between 15 and 30 deg. C (59 and 86 deg. F), unless otherwise specified by manufacturer. /Sunscreen agents, topical/

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state White to off-white or light yellow powder.
    Colour Colorless crystals
    Odour no data available
    Melting point/ freezing point 227°C(lit.)
    Boiling point or initial boiling point and boiling range 150-160°C/5mmHg(lit.)
    Flammability no data available
    Lower and upper explosion limit / flammability limit no data available
    Flash point 100°C
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility less than 1 mg/mL at 20°C
    Partition coefficient n-octanol/water (log value) no data available
    Vapour pressure 5.26E-06mmHg at 25°C
    Density and/or relative density 1.324
    Relative vapour density no data available
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    no data available

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    no data available

    10.6 Hazardous decomposition products

    no data available

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral > 12.8 g/kg
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: no data available
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    AEROBIC: 2-Hydroxy-4-methoxybenzophenone, present at 100 mg/L, reached 4% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1).

    12.3 Bioaccumulative potential

    BCF values ranging from 33-160 were measured using orange-red killifish (Oryzias latipes) which were exposed over an 8-week period(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is moderate to high(SRC).

    12.4 Mobility in soil

    The Koc of 2-hydroxy-4-methoxybenzophenone is estimated as 2,700(SRC), using a log Kow of 3.79(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-hydroxy-4-methoxybenzophenone is expected to have slight mobility in soil.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.2 UN Proper Shipping Name

    ADR/RID: unknown
    IMDG: unknown
    IATA: unknown

    14.3 Transport hazard class(es)

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.4 Packing group, if applicable

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.5 Environmental hazards

    ADR/RID: yes IMDG: yes IATA: yes

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    2-Hydroxy-4-methoxybenzophenone 2-Hydroxy-4-methoxybenzophenone 131-57-7 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Not Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 10, 2017
    Revision Date Aug 10, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C14 H12 O3 0.048 g : 0.5 ml CDCl3
    2-hydroxy-4-methoxybenzophenone

    Assign. Shift(ppm)
    A 12.68
    B 7.75 to 7.29
    C 6.51
    D 6.403
    E 3.845

    IR : KBr discExpand
    Mass Expand
    Raman : 4880 A,200 M,powderExpand
    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 7400 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral TDLo - Lowest published toxic dose Rodent - rat 189 gm/kg/90D-C 1.Kidney, Ureter, Bladder-changes in tubules (including acute renal failure, acute tubular necrosis)
    2.Blood-changes in other cell count (unspecified)
    3.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    Oral TDLo - Lowest published toxic dose Rodent - rat 8246 mg/kg/2W-C 1.Liver-changes in liver weight
    2.Kidney, Ureter, Bladder-changes in bladder weight
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