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    CAS No.: 106-48-9 Formula: C6H5ClO Molecular Weight: 128.55600
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    CAS No.: 106-48-9 Formula: C6H5ClO Molecular Weight: 128.55600
    Suppliers: All (82) China Suppliers (82) Price Available (10) Contractor (16)


    4-Chlorophenol is a halogenated phenol derivative and the building block of various pharmaceutical goods.

    Numbering system

    BRN number 507004
    EINECS number 203-402-6
    MDL number MFCD00002318
    RTECS number SK2800000


    Appearance & Physical State off-white to light tan crystals or powder
    Density 1.306
    Boiling Point 220oC
    Melting Point 41-45oC
    Flash Point 121oC
    Refractive Index 1.5579
    Water Solubility 2.7 g/100 mL (20 oC)
    Stability Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.
    Storage Condition 0-6oC
    Vapor Pressure 1 mm Hg ( 49.8 °C)

    Safety Info

    RTECS SK2800000
    Hazard Class 6.1
    Safety Statements S28-S61
    HS Code 2908191000
    WGK Germany 2
    Packing Group III
    RIDADR UN 2904/2905/2020
    Risk Statements R20/21/22; R51/53
    Hazard Codes Xn
    Hazard Declaration H302; H312; H332; H411
    Symbol GHS07, GHS09
    Caution Statement P273; P280
    Signal Word Warning
    SDS 1.0 Expand

    SDS 1.0

    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search


    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 10, 2017

    Revision Date: Aug 10, 2017


    1.1 GHS Product identifier

    Product name 4-chlorophenol

    1.2 Other means of identification

    Product number -
    Other names p-Chlorophenol

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only.
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    Acute toxicity - Dermal, Category 4

    Acute toxicity - Inhalation, Category 4

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

    2.2 GHS label elements, including precautionary statements

    Signal word


    Hazard statement(s)

    H302 Harmful if swallowed

    H312 Harmful in contact with skin

    H332 Harmful if inhaled

    H411 Toxic to aquatic life with long lasting effects

    Precautionary statement(s)

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P273 Avoid release to the environment.


    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P391 Collect spillage.




    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification


    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    4-chlorophenol 4-chlorophenol 106-48-9 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Inhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media


    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    Phenolic cmpd in wastewater are oxidized with hydrogen peroxide catalyzed by iron(3+)-iron(2+). When the wt ratio of phenol:hydrogen peroxide is 1:3 and iron 5-100 ppm, more than 95% of the phenols are removed in 30 min from a 500 ppm phenol soln at pH 5-6 and 25-50°C. /Phenolic cmpd/

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Separated from strong oxidants and food and feedstuffs. Well closed.Store in tightly closed containers in a cool, well ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to precess containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. /Monochlorophenols/

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state off-white to light tan crystals or powder
    Colour Needle like, white to straw-colored crystals
    Odour Characeteristic phenolic odor
    Melting point/ freezing point -20°C(lit.)
    Boiling point or initial boiling point and boiling range 220°C(lit.)
    Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit no data available
    Flash point 121°C
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH 1% solution is acidic to litmus
    Kinematic viscosity 5 cP at 50°C
    Solubility In water:2.7 g/100 mL (20 oC)
    Partition coefficient n-octanol/water (log value) log Kow = 2.39
    Vapour pressure 1 mm Hg ( 49.8 °C)
    Density and/or relative density 1.306g/mLat 25°C(lit.)
    Relative vapour density 4.4 (Relative to Air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Volatile with steam

    10.3 Possibility of hazardous reactions

    COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAMECHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 42.22°C.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    no data available

    10.6 Hazardous decomposition products

    When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Mouse oral 860 mg/kg. /From table/
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50; Species: Danio rerio (Zebra danio, length 2.5 cm); Conditions: freshwater, static, 22°C, pH 7.8-8, hardness 150 mg/L CaCO3; Concentration: 3500-10000 ug/L for 24 hr
    • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age <72 hr); Conditions: freshwater, static, 20°C, pH 7.8-8.2, hardness 200 mg/L CaCO3, dissolved oxygen > or =2.27 mg/L; Concentration: 8070 ug/L for 24 hr (95% confidence interval: 5790-10340 ug/L); Effect: intoxication, immobilization />95% purity
    • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae, exponential growth phase, 50000 cells/mL); Conditions: freshwater, static, 21°C; Concentration: 38000 ug/L for 96 hr; Effect: growth, general /formulated product
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    ... Complete dechlorination and aromatic ring degradation of ... 4-chlorophenol ... by 2,4-D grown cells of an Arthrobacter species isolated from slit loam.

    12.3 Bioaccumulative potential

    BCFs of 6.0 to 18 for a test concn of 40 ppb and BCFs of 11 to 52 for test concn of 4 ppb was determined for 4-chlorophenol in carp and 42 days exposure(1). The BCF of 4-chlorophenol in goldfish ranged from 10 to 15(2,3). According to a classification scheme(4), these BCF's suggest the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    Experimentally determined Kocs in various soil conditions range from 70 to 485.6(1,3,6). The Koc in clay loam soil was determined to be 71(1). A Koc of 70 was reported for 4-chlorophenol in Brookston clay loam soil(3). Adsorption of 4-chlorophenol to the organo-clay Bentone 24 has been shown to be pH sensitive; it was 48.5% adsorbed by Bentone 24 in aqueous solution at pH 8.0 and 7.7% adsorbed by Bentone 18C at pH 7.7(4). 4-Chlorophenol did not appear to be sorbed in an experiment in a sandy aquifer(5). A Koc of 485.6 was reported in a European silt loam soil(6). According to a classification scheme(2), Koc values of zero to 50 are very highly mobile, 50 to 150 are highly mobile, and 150 to 500 are moderately mobile.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN2020 IMDG: UN2020 IATA: UN2020

    14.2 UN Proper Shipping Name


    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable


    14.5 Environmental hazards

    ADR/RID: yes IMDG: yes IATA: yes

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    4-chlorophenol 4-chlorophenol 106-48-9 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 10, 2017
    Revision Date Aug 10, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%


    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3


    C6 H5 Cl O 0.046 g : 0.5 ml CDCl3

    Assign. Shift(ppm)
    A 7.172
    B 6.755
    C 5.23

    IR : liquid filmExpand
    Mass spectrum (electron ionization)Expand
    Raman : 4880 A,200 M,powderExpand
    UV/Visible spectrumExpand
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