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    Benzoyl chloride
    CAS No.: 98-88-4 Formula: C7H5ClO Molecular Weight: 140.56700
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    Benzoyl chloride

    CAS No.: 98-88-4 Formula: C7H5ClO Molecular Weight: 140.56700
    Suppliers: All (102) China Suppliers (102) Price Available (12) Contractor (18)

    Description

    Benzoyl chloride, also known as benzenecarbonyl chloride, is an organochlorine compound with the formula C6H5COCl. It is a colourless, fuming liquid with an irritating odour. It is mainly useful for the production of peroxides but is generally useful in other areas such as in the preparation of dyes, perfumes, pharmaceuticals, and resins.

    Basic Info

    Chemical Name Benzoyl chloride
    Synonyms

    α-Chlorobenzaldehyde; benzoic chloride; Benzoylchloride; Bz chloride; benzoic acid chloride; Benzenecarbonyl chloride; phenylcarbonyl chloride; Expand

    CAS No. 98-88-4
    Molecular Formula C7H5ClO
    Molecular Weight 140.56700
    PSA 17.07000
    LogP 2.06560

    Numbering system

    EINECS number 202-710-8
    MDL number MFCD00000653

    Properties

    Appearance & Physical State Colourless liquid
    Density 1.2188
    Boiling Point 198oC
    Melting Point -1oC
    Freezing Point -1℃
    Flash Point 68oC
    Refractive Index 1.552-1.554
    Water Solubility reacts
    Stability Stable. Combustible. Incompatible with strong oxidizing agents, water, alcohols, strong bases. Reacts violently with DMSO and vigorously with alkalies.
    Storage Condition Store at 0-5oC
    Vapor Density 4.88 (vs air)
    Vapor Pressure 1 mm Hg ( 32 °C)

    Safety Info

    RTECS DM6600000
    Hazard Class 8
    Safety Statements S26-S36/37/39-S45
    HS Code 2916320000
    WGK Germany 1
    Packing Group II
    RIDADR UN 1736
    Risk Statements R34
    Hazard Codes C
    Caution Statement P280; P305 + P351 + P338; P310
    Symbol GHS05, GHS07
    Hazard Declaration H302 + H312 + H332; H314; H317
    Signal Word Danger
    SDS 1.0 Expand

    SDS 1.0

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    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search

    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name Benzoyl chloride

    1.2 Other means of identification

    Product number -
    Other names Benzoyl chloride

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Acute toxicity - Oral, Category 4

    Acute toxicity - Dermal, Category 4

    Skin corrosion, Category 1B

    Skin sensitization, Category 1

    Acute toxicity - Inhalation, Category 4

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H302 Harmful if swallowed

    H312 Harmful in contact with skin

    H314 Causes severe skin burns and eye damage

    H317 May cause an allergic skin reaction

    H332 Harmful if inhaled

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P310 Immediately call a POISON CENTER/doctor/…

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Benzoyl chloride Benzoyl chloride 98-88-4 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. See Notes.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . Wear protective gloves when administering first aid.

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Rest. Do NOT induce vomiting. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    INHALATION: may irritate eyes, nose and throat. INGESTION: causes acute discomfort. SKIN: causes irritation and burning. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic Treatment: Establish a patent airway. Suction if necessary. Encourage patient to take deep breaths. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Irritating materials/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Use foam, carbon dioxide, dry chemical and water fog. /Do not use/ water spray. Do not allow water to enter container.

    5.2 Specific hazards arising from the chemical

    Special Hazards of Combustion Products: Highly poisonous phosgene gas may be formed in fires. Behavior in Fire: At fire temperatures the compound may react violently with water or steam. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

    6.3 Methods and materials for containment and cleaning up

    Neutralizing agents for acids and caustics: soda ash and water: lime.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    See Chemical Dangers. Separated from food and feedstuffs and incompatible materials. Dry. Well closed.Store in a cool, dry, well-ventilated location. Outside or detached storage is preferred. Store away from oxidizing materials.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Colourless liquid
    Colour Transparent, colorless liquid
    Odour Penetrating odor
    Melting point/ freezing point 258°C(lit.)
    Boiling point or initial boiling point and boiling range 198°C(lit.)
    Flammability Combustible. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit Lower flammable limit: 1.1% by volume; Upper flammable limit: 7.1% by volume
    Flash point 72°C
    Auto-ignition temperature 568.89°C
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility In water:reacts
    Partition coefficient n-octanol/water (log value) no data available
    Vapour pressure 1 mm Hg ( 32 °C)
    Density and/or relative density 1.211g/mLat 25°C(lit.)
    Relative vapour density 4.88 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Stable under recommended storage conditions.

    10.3 Possibility of hazardous reactions

    Moderate, when exposed to heat or flame.The vapour is heavier than air.BENZOYL CHLORIDE reacts violently with protic solvents such as alcohols, with amines and amides (for example dimethylformamide [Bretherick 1979 p. 6] ) and with inorganic bases. Causes the violent decomposition of dimethyl sulfoxide [Chem. Eng. News 35(9): 87 1957]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Friedel-Crafts acylation of naphthalene using benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent [Clar, E. et al., Tetrahedron, 1974, 30, 3296].

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Dimethyl sulfoxide decomposition is violent on contact with... benzoyl chloride. ...

    10.6 Hazardous decomposition products

    When heated to decomposition it emits toxic fumes of /hydrogen chloride/

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 2460 mg/kg
    • Inhalation: LC50 Rat inhalation 1870 mg/cu m 2 hrs
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    Evaluation: There is limited evidence in humans for the carcinogenicity of ... benzoyl chloride. ... There is inadequate evidence in experimental animals for the carcinogenicity of benzoyl chloride. Overall evaluation: Combined exposures to alpha-chlorinated toluenes and benzoyl chloride are probably carcinogenic to humans (Group 2A). /alpha-Chlorinated toluenes & benzoyl chloride/

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 43 mg/L/24 hr; 35 mg/L/48 hr; 35 mg/L/96 hr /Conditions of bioassay not specified
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    No data were available, but since benzoyl chloride hydrolysis is so rapid, biodegradation is not expected to be an important factor in the fate of benzoyl chloride. (SRC)

    12.3 Bioaccumulative potential

    No data were available, but due to the rapid rate of hydrolysis of benzoyl chloride, bioconcentration is not expected to be an important factor in the fate of benzoyl chloride. (SRC)

    12.4 Mobility in soil

    No data were available, but due to the rapid rate of hydrolysis of benzoyl chloride, the compound is not expected to persist in the soil. (SRC)

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1736 IMDG: UN1736 IATA: UN1736

    14.2 UN Proper Shipping Name

    ADR/RID: BENZOYL CHLORIDE
    IMDG: BENZOYL CHLORIDE
    IATA: BENZOYL CHLORIDE

    14.3 Transport hazard class(es)

    ADR/RID: 8 IMDG: 8 IATA: 8

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Benzoyl chloride Benzoyl chloride 98-88-4 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C7 H5 Cl O 0.04 ml : 0.5 ml CDCl3
    benzoyl chloride

    Assign. Shift(ppm)
    A 8.11
    B 7.69
    C 7.49

    IR : liquid filmExpand
    Mass spectrum (electron ionization)Expand
    Raman : 4880 A,100M,liquidExpand

    GC Analysis

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    Capillary VF-5MS - 1095.1 custom temperature program
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