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    Bromoethane
    CAS No.: 74-96-4 Formula: C2H5Br Molecular Weight: 108.96500
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    Bromoethane

    CAS No.: 74-96-4 Formula: C2H5Br Molecular Weight: 108.96500
    Suppliers: All (89) China Suppliers (89) Price Available (11) Contractor (17)

    Description

    Bromoethane is used in the synthesis of novel non-competitive antagonists of kainate Glu1/Glu2 receptors. Also it is used in the synthesis of tryptophan analogues. Is used in the synthesis of Tamoxifen as an antibiotic.

    Basic Info

    Chemical Name Bromoethane
    Synonyms

    Hydrobromic ether; Bromure d'ethyle; ethyl btomide; Ethane,bromo; 1-bromo ethane; Ethane, bromo-; Monobromoethane; Bromic ether; ethylbromide; Expand

    CAS No. 74-96-4
    Molecular Formula C2H5Br
    Molecular Weight 108.96500
    PSA 0.00000
    LogP 1.40120

    Numbering system

    MDL number MFCD00000232
    EINECS number 200-825-8

    Properties

    Appearance & Physical State colourless liquid with an ether-like odour
    Density 1.46
    Boiling Point 37-40oC
    Melting Point -119oC
    Flash Point -23oC
    Refractive Index 1.4225-1.4245
    Water Solubility 0.91 g/100 mL (20 oC)
    Stability Stable. Highly flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with alkali metals, aluminium, magnesium, strong bases, water, strong oxidizing agents. May be light sensitive.
    Storage Condition Refrigerator
    Vapor Density ~3.75 (vs air)
    Vapor Pressure 25.32 psi ( 55 °C)

    Safety Info

    RTECS KH6475000
    Hazard Class 6.1
    Safety Statements S36/37
    HS Code 2903399090
    WGK Germany 1
    Packing Group II
    RIDADR UN 1891
    Risk Statements R11; R20/22; R40
    Hazard Codes F
    SDS 1.0 Expand

    SDS 1.0

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    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017

    1.Identification

    1.1 GHS Product identifier

    Product name Bromoethane

    1.2 Other means of identification

    Product number -
    Other names Hydrobromic ether

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Intermediates,Ion exchange agents
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 2

    Acute toxicity - Oral, Category 4

    Acute toxicity - Inhalation, Category 4

    Carcinogenicity, Category 2

    2.2 GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H302 Harmful if swallowed

    H332 Harmful if inhaled

    H351 Suspected of causing cancer

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P201 Obtain special instructions before use.

    P202 Do not handle until all safety precautions have been read and understood.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P308+P313 IF exposed or concerned: Get medical advice/ attention.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification

    none

    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    Bromoethane Bromoethane 74-96-4 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Bromine, methyl bromide, and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.

    5.2 Specific hazards arising from the chemical

    Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Evacuate danger area! Consult an expert! Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable metal containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Personal protection: chemical protection suit including self-contained breathing apparatus.

    6.3 Methods and materials for containment and cleaning up

    Absorb the spills with paper towels or the like materials. Place in hood to evaporate. Dispose by burning the towel.

    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from incompatible materials. Cool. Dry. Well closed. Ventilation along the floor.Outdoor or detached storage is preferable. Indoor storage should be in a standard flammable liquid storage room.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    After reviewing available published literature, NIOSH provided comments to OSHA on August 1, 1988, regarding the "Proposed Rule on Air Contaminants" (29 CFR 1910, Docket No. H-020). In these comments, NIOSH questioned whether the PELs proposed for ethyl bromide [TWA 200 ppm; STEL 250 ppm] were adequate to protect workers from recognized health hazards.

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state colourless liquid with an ether-like odour
    Colour Colorless to yellow liquid ... [Note: A gas above 101 degrees F].
    Odour ... Ether-like odor.
    Melting point/ freezing point 188°C(lit.)
    Boiling point or initial boiling point and boiling range 38°C
    Flammability Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Extremely flammable.
    Lower and upper explosion limit / flammability limit % BY VOL: LOWER FLAMMABLE LIMIT: 6.8; UPPER FLAMMABLE LIMIT: 8.0
    Flash point -23°C(lit.)
    Auto-ignition temperature 511.11°C
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity 0.379 cP @ 25°C
    Solubility In water:0.91 g/100 mL (20 oC)
    Partition coefficient n-octanol/water (log value) log Kow = 1.61
    Vapour pressure 25.32 psi ( 55 °C)
    Density and/or relative density 1.46
    Relative vapour density ~3.75 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Conditions contributing to instability: heat

    10.3 Possibility of hazardous reactions

    Dangerously flammable by heat, open flame (sparks), oxidizers.The vapour is heavier than air and may travel along the ground; distant ignition possible.ETHYL BROMIDE will react with steam to produce toxic and corrosive fumes. It can react vigorously with oxidizers. It reacts with strong bases. It also reacts with chemically active metals such as sodium, potassium, calcium, powdered aluminum, zinc and magnesium. It will attack some forms of plastics, rubber and coatings.

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Explosion may occur by an impact with the mixture of this substance with alkali metals.

    10.6 Hazardous decomposition products

    READILY DECOMPOSES WHEN HEATED TO EMIT TOXIC FUMES OF /BROMINE/.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 1350 mg/kg
    • Inhalation: LC50 Rat inhalation 27,000 ppm/1 hr
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    Evaluation: No epidemiological data relevant to the carcinogenicity of bromoethane were available. There is limited evidence in experimental animals for the carcinogenicity of bromoethane. Overall evaluation: Bromoethane is not classifiable as to its carcinogenicity to humans (Group 3).

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: no data available
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    Ethyl bromide, present at 100 mg/l, reached 13-45% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1).

    12.3 Bioaccumulative potential

    An estimated BCF of 3.5 was calculated for ethyl bromide(SRC), using a log Kow of 1.61(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    12.4 Mobility in soil

    The Koc of ethyl bromide is estimated as 179(SRC), using a log Kow of 1.61(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that is expected to have moderate mobility in soil.

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1891 IMDG: UN1891 IATA: UN1891

    14.2 UN Proper Shipping Name

    ADR/RID: ETHYL BROMIDE
    IMDG: ETHYL BROMIDE
    IATA: ETHYL BROMIDE

    14.3 Transport hazard class(es)

    ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

    14.4 Packing group, if applicable

    ADR/RID: II IMDG: II IATA: II

    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    Bromoethane Bromoethane 74-96-4 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%

    References

    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3

    Collapse

    C2 H5 Br 0.02 ml : 0.5 ml CDCl3
    ethyl bromide

    Assign. Shift(ppm)
    A 3.427
    B 1.679

    IR : liquid filmExpand
    Mass spectrum (electron ionization)Expand
    Raman : 4880 A,200 M,liquidExpand
    ESR : MICROWAVE DISCHARGE IN MIXTURE WITH HG VAPORExpand

    GC Analysis

    Total 20 Documents >>
    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed OV-1 100. 524. isothermal
    Packed OV-1 125. 529. isothermal
    Packed OV-1 75. 517. isothermal
    Packed SE-30 100. 522. isothermal
    Packed Porapack Q 200. 484. isothermal
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