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    CAS No.: 110-86-1 Formula: C5H5N Molecular Weight: 79.09990
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    CAS No.: 110-86-1 Formula: C5H5N Molecular Weight: 79.09990
    Suppliers: All (116) China Suppliers (116) Price Available (20) Contractor (5)

    Basic Info

    Chemical Name pyridine

    Pyridine; Pyridine,nonaqueous titration grade; Pyridine,AcroSeal,Extra Dry;

    CAS No. 110-86-1
    Molecular Formula C5H5N
    Molecular Weight 79.09990
    PSA 12.89000
    LogP 1.08160

    Numbering system

    MDL number MFCD00011732
    EINECS number 203-809-9
    BRN number 103233
    RTECS number UR8400000
    PubChem number 24856420


    Appearance & Physical State Clear clean liquid with characteristic odour
    Density 0.978
    Boiling Point 115-116oC
    Melting Point -42oC
    Freezing Point -42℃
    Flash Point 17oC
    Refractive Index 1.5085-1.5105
    Water Solubility Miscible
    Stability Stable. Flammable. Incompatible with strong oxidizing agents, strong acids.
    Storage Condition Store at RT.
    Vapor Density 2.72 (vs air)
    Vapor Pressure 23.8 mm Hg ( 25 °C)

    Safety Info

    RTECS UR8400000
    Hazard Class 3
    Safety Statements S26-S28
    HS Code 2933990090
    WGK Germany 2
    Packing Group II
    RIDADR UN 1282
    Risk Statements R11; R20/21/22
    Hazard Codes F; Xn
    Caution Statement P210; P261; P280; P305 + P351 + P338; P370 + P378; P403 + P235
    Hazard Declaration H225; H302 + H312 + H332; H315; H319
    Signal Word Danger
    Symbol GHS02, GHS07
    SDS 1.0 Expand

    SDS 1.0

    Download/Modify | Technical supported by XiXisys.com. For US version, EU version (23 languages) and more, please refer to xixisys.com/en/sds/search


    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 12, 2017

    Revision Date: Aug 12, 2017


    1.1 GHS Product identifier

    Product name pyridine

    1.2 Other means of identification

    Product number -
    Other names Pyridine,nonaqueous titration grade

    1.3 Recommended use of the chemical and restrictions on use

    Identified uses For industry use only. Benzidines/Aromatic amines
    Uses advised against no data available

    1.4 Supplier's details

    Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
    Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
    Xuhui District, Shanghai, China
    Telephone +86(21)64956998
    Fax +86(21)54365166

    1.5 Emergency phone number

    Emergency phone number +86-400-6021-666
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 2

    Acute toxicity - Oral, Category 4

    Acute toxicity - Dermal, Category 4

    Acute toxicity - Inhalation, Category 4

    2.2 GHS label elements, including precautionary statements

    Signal word


    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H302 Harmful if swallowed

    H312 Harmful in contact with skin

    H332 Harmful if inhaled

    Precautionary statement(s)

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection.

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.


    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P312 Call a POISON CENTER/doctor/…if you feel unwell.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.


    P403+P235 Store in a well-ventilated place. Keep cool.


    P501 Dispose of contents/container to ...

    2.3 Other hazards which do not result in classification


    3.Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    pyridine pyridine 110-86-1 none 100%

    4.First-aid measures

    4.1 Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

    In case of skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

    In case of eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    If swallowed

    Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/

    5.Fire-fighting measures

    5.1 Extinguishing media

    Suitable extinguishing media

    Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Solid streams of water may be ineffective. Use water spray to keep fire-exposed containers cool.

    5.2 Specific hazards arising from the chemical

    Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2 Environmental precautions

    Personal protection: self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up


    7.Handling and storage

    7.1 Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Well closed.OUTSIDE OR DETACHED STORAGE IS PREFERABLE. ISOLATE FROM POWERFUL OXIDIZING MATERIALS AND ACIDS.

    8.Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (15 mg/cu m).

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state Clear clean liquid with characteristic odour
    Colour Colorless to yellow liquid.
    Odour Sharp, nauseating
    Melting point/ freezing point -42oC
    Boiling point or initial boiling point and boiling range 115°C(lit.)
    Flammability Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.
    Lower and upper explosion limit / flammability limit LOWER 1.8%; UPPER 12.4%
    Flash point 17°C
    Auto-ignition temperature 481.67°C
    Decomposition temperature no data available
    pH 8.5 (0.2 molar soln in water)
    Kinematic viscosity no data available
    Solubility In water:Miscible
    Partition coefficient n-octanol/water (log value) log Kow = 0.65
    Vapour pressure 23.8 mm Hg ( 25 °C)
    Density and/or relative density 0.978g/mLat 25°C(lit.)
    Relative vapour density 2.72 (vs air)
    Particle characteristics no data available

    10.Stability and reactivity

    10.1 Reactivity

    no data available

    10.2 Chemical stability

    Mixtures with formamide + iodine + sulfur trioxide are storage hazards, releasing carbon dioxide & sulfuric acid.

    10.3 Possibility of hazardous reactions

    Pyridine is a flammable ... liquid.The vapour is heavier than air and may travel along the ground; distant ignition possible.PYRIDINE is a base. Reacts exothermically with acids. During preparation of a complex of pyridine with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of pyridine (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing pyridine in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, pyridine, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in pyridine solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials


    10.6 Hazardous decomposition products

    When pyridine is heated to decomposition, cyanide fumes are released.

    11.Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 1.58 g/kg
    • Inhalation: LC50 Rat inhalation 9000 ppm for 1 hr
    • Dermal: LD50 Guinea pig percutaneous 1.0 - 2.0 ml/kg

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    A3: Confirmed animal carcinogen with unknown relevance to humans.

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 106 mg/l/96 hr, flow-through bioassay with measured concentrations, 24.1°C, dissolved oxygen 7.4 mg/l, hardness 47.4 mg/l CaCO3, alkalinity 240 mg/l CaCO3, and pH 7.73.
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    Results of biodegradability screening tests for pyridine using sewage or activated sludge inocula give mixed results ranging from rapid to no degradation(1-5,7). Although biodegradability is improved in longer tests employing a more vigorous inocula, sometimes the same test gives disparate results(1-4,7). Variations in the particular sewage or activated sludge inoculum would affect test results. One investigator obtained results ranging from 97% degradation in 6 days to no degradation in 30 days in 6 different standard tests(1). After a preincubation step was added to one test in which no degradation was observed in 19 days, degradability increased to 91%(3). However the closed bottle test which employs only a drop of sewage effluent as an inoculum, registered no degradation even with a preincubation step(1,3). Tests that were designed to simulate biological treatment plants resulted in complete and rapid removal of pyridine(1,9). In one test that employed a soil suspension as an inoculum, 100% degradation was obtained in 66-170 days(6). When this test was repeated under anaerobic conditions, degradation was more rapid(6). Complete degradation was obtained in 32-66 days(6). When 2 micromoles/g of pyridine was incubated with a silt loam soil, 11.7% remained after 4 days and none remained after 8 days(8). The biodegradation rate constant for pyridine in water was 0.0033 - 0.018 per hour which corresponds to half-lives of 39-210 hours(10).

    12.3 Bioaccumulative potential

    The bioconcentration factor in guppies exposed to an unspecified concentration of pyridine over a 2-day incubation period was 88(1). According to a classification scheme(2), this BCF suggests the bioconcentration in aquatic organisms moderate.

    12.4 Mobility in soil

    The Koc of pyridine is estimated as 50(SRC), using a measured log Kow of 0.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that pyridine is expected to have high mobility in soil. The pKa of pyridine is 5.23(4), which indicates that pyridine will partially exist in the protonated form under acidic conditions and cations adsorb more strongly to soil surfaces than neutral molecules(SRC). The adsorption of pyridine to a basic subsoil (pH 8.15, 0.58% organic carbon) is negligible, while in an acidic subsoil (pH 4.85, O.24% organic carbon), the Freundlich adsorption constant was measured to be 5.78 and the slope 0.679(5). This suggests a cationic adsorption mechanism as pyridine is predominantly in its protonated form. Pyridine adsorbs to colloidal particles of sodium montmorillonite and kaolinite, a process which is attributed to cation exchange and is a function of pH(5). Adsorption is at a minimum at pH 1 and 11 and reaches a maximum at pH 4 for the montmorillonite and pH 5.5 for the kaolinite where the adsorption constants are 60 and 10, respectively(6).

    12.5 Other adverse effects

    no data available

    13.Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1 UN Number

    ADR/RID: UN1282 IMDG: UN1282 IATA: UN1282

    14.2 UN Proper Shipping Name


    14.3 Transport hazard class(es)

    ADR/RID: 3 IMDG: 3 IATA: 3

    14.4 Packing group, if applicable


    14.5 Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    pyridine pyridine 110-86-1 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Listed.
    China Catalog of Hazardous chemicals 2015 Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
    Vietnam National Chemical Inventory Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

    16.Other information

    Information on revision

    Creation Date Aug 12, 2017
    Revision Date Aug 12, 2017

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%


    • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
    • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
    • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
    • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
    • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
    • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
    • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
    MSDS Expand
    1H NMR : 90 MHz in CDCl3Expand

    NMR Spectrum 1H NMR : 90 MHz in CDCl3


    C5 H5 N 4.0 mol% in CDCl3

    Assign. Shift(ppm)
    A 7.277
    B 7.655
    C 8.613

    IR : liquid filmExpand
    Mass spectrum (electron ionization)Expand
    Raman : 4880 A,100M,liquidExpand
    UV/Visible spectrumExpand
    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Administration onto the skin Standard Draize test Rodent - rabbit 500 mg/24H -
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 891 mg/kg 1.Sense Organs and Special Senses (Eye)-ptosis
    2.Behavioral-somnolence (general depressed activity)
    Inhalation LC50 - Lethal concentration, 50 percent kill Rodent - rat 28500 mg/m3/1H 1.Sense Organs and Special Senses (Eye)-lacrimation
    2.Behavioral-somnolence (general depressed activity)
    3.Lungs, Thorax, or Respiration-dyspnea
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